VIRAL ACTIVATION TRANSFUSION STUDY (VATS)

这项研究旨在确定输注同种异体血液 对HIV-1感染者会导致免疫激活，从而导致 诱导HIV-1和/或CMV复制，以及这是否对 影响临床预后。这项研究将确定捐赠者的角色 通过检测白细胞在产生这种激活中的作用 滤过性去除白细胞对病毒诱导和临床的影响 进步。最后，这项研究将检验长期持久性 以确定输血后循环供者淋巴细胞的数量 隐匿性移植物抗宿主病可能是艾滋病的重要发病因素 病人。

This study is designed to determine if transfusion of allogenic blood to HIV-1-infected persons leads to immune activation and consequent induction of HIV-1 and/or CMV replication, and whether this adversely affects clinical prognosis. The study will determine the role of donor leukocytes in producing this activation by examining the effect of removing leukocytes by filtration on viral induction and clinical progression. Finally, the study will examine the long-term persistence of circulating donor lymphocytes after transfusion to determine if occult graft-versus-host disease may be a significnata ocurrence in AIDS patients.