EFFECT OF PLANT PHENOLIC COMPOUNDS ON HUMAN COLON EPITHELIAL CELLS

非类固醇抗炎药(NSAIDs)可预防高血压的发生 普通人群中的结直肠癌转移症。流行病学研究表明 估计经常使用这些化合物可以降低死亡率 结直肠癌的发病率高达50%。尽管事实是 这些化合物是世界上使用最广泛的药物之一， 这些化合物预防结肠癌的机制还不完全清楚。 明白了。流行病学研究还表明，摄入一种 富含水果和蔬菜的饮食可降低糖尿病的发病率和死亡率 死于结直肠癌。水果中所含的确切化学成分 而拥有这些抗癌特性的蔬菜还没有被 已确认身份。然而，有几种已知的化合物在 经常食用的水果和蔬菜-植物酚类物质，如 姜黄素、芦丁和栎素-它们具有生物学特性 耐人寻味的类似于非甾体抗炎药。因此，这样做的理由 这项研究是为了确定这些植物酚类化合物 对结肠粘膜上皮细胞的影响类似于舒林酸， 一种经典的非甾体抗炎药化学预防药物。这项研究验证了这一假设 植物中的酚类化合物：姜黄素、槲皮素和芦丁 影响细胞周转的生物标志物及花生四烯酸的测定 (Aa)人大肠粘膜上皮细胞的代谢 活体内的肠道。此外，它还检验了这样一个假设，即 这些化合物在这些参数上与舒林酸相似， 化学预防非甾体类抗炎药。

Nonsteroidal antiinflammatory drugs (NSAIDs) prevent the development of colorectal conver in the general population. Epidemiological studies have estimated that regular use of these compounds can reduce the mortality rate from colorectal cancer by as much as 50%. Despite the fact that these compounds are among the most widely used pharmaceuticals worldwide, the mechanisms by which these compunds prevent colon cancer is not fully understood. Epidemiological studies have also shown that consumption of a diet rich in fruits and vegetables reduces the incidence of and mortality from colorectal cancer. The exact chemical components contained in fruits and vegeatbles that possess these anti-cancer properties have not been identified. However, there are several compounds known to be abundant in commonly consumed fruits and vegetables---the plant phenolics such as curcumin, rutin, and quercetin---that have biological properties intriguingly similar to those of the NSAIDs. Therefore, the rationale for this study is to determine whether these plant phenolic compounds influence the epithelial cells of the colonic mucosa similar to sulindac, a classical NSAID chemopreventive agent. This study tests the hypothesis that the plant phenolic compounds: curcumin, quercetin, and rutin influence biomarkers of cell turnover and measurements of arachidonic acid (AA) metabolism in the epithelial cells of the mucosa of the human large intestine in vivo. In addition, it tests the postulate that the effect of these compunds on these parameters are similar to those of sulindac, a chemopreventive NSAID.