PARTIAL LIQUID VENTILLATION WITH AP0141 IN TERM INFANTS WITH SEVERE LUNG DIS

本研究的主要目的是比较传统通气 通过血气变化测量的部分液体通气治疗 急性和急性期的Pa02、PaC02、BE值和肺功能， 延长干预时间。第二个目标是让 研究者报告死亡或从ICU出院的时间， 液体安装的开始。幸存者的人数将被报告 也 迄今为止，已经招募了两名婴儿，一名不到1公斤，另一名不到1公斤。 不到2公斤。两名患者均随机接受部分液体治疗， 通风.两人在4小时内呼吸都有明显改善 在开始治疗后。唯一的副作用是短暂的分泌过多 发生在治疗后期或治疗后， 停止了。

The primary objective of this study is to compare conventional ventilation therapy to partial liquid ventilation as measured by changes in blood gas values (Pa02, PaC02, BE) and pulmonary function during the acute and extended intervention periods. The secondary objective is to have the investigators report time to death or discharge from the ICU after beginning of liquid installation. The number of survivors will be reported as well. Two infants have been enrolled thus far, one less than 1 kg and the other less than 2 kg. Both patients were randomized to partial liquid ventilation. Both had dramatic respiratory improvement within 4 hours after starting therapy. The only side effect was transient hypersecretion which occurred either late into the course of therapy or after therapy was discontinued.