TIMED BREEDING STUDIES IN MACAQUES

我们为其他需要怀孕的调查人员提供服务 已知胎龄的猴子并监测胎儿生长情况 恒河猴(猕猴)。猴子的周期是人为的 通过每天注射促黄体素刺激黄体期 黄体酮(5 mg/天)，连服10天。雌性与雄性配对在 末次注射黄体酮后第14至21天。过去的研究 表明排卵和受孕发生在16至18天后 黄体酮注射。成功率，基于以下时间的存活胎儿 怀孕21天，第一个周期的平均配合率从60%到85%， 这取决于女性的年龄和健康状况。胎儿发育 由每周的超声波检查监测，直到分娩。在… 根据胎龄的不同，每次检查的测量结果都是 测量孕囊长度、头臀长、心率、股骨 长度和两部分直径。这些测量允许 确定胎儿年龄和偏离正常生长的情况 参数。对胎盘进行评估以确定 任何异常情况。这些程序为调查人员提供了 在特定阶段进行研究的能力

We provide a service to other investigators who need pregnant monkeys of known gestational ages and to monitor fetal growth in rhesus monkeys (Macaca mulatta). The monkeys' cycles are artificially stimulated to induce a luteal phase by the daily injection of progesterone (5 mg/day) for 10 days. Females are paired with males on days 14 to 21 after the last progesterone injection. Past studies indicate that ovulation and conception occurs on day 16 to 18 after the progesterone injections. Success rate, based on viable fetus at 21 days gestation, averages from 60% to 85% for first cycle matings, depending on age and health status of the females. Fetal development is monitored by weekly ultrasound exams until time of parturition. At each exam measurements are taken, depending on gestational age, to determine gestational sac length, crown-rump length, heart rate, femur length, and bipartial diameter. These measurements allow for determination of fetal age and of deviations from normal growth parameters. Evaluation of the placental disks are made to determine any anomalies. These procedures provide investigators with the ability to conduct studies at specific stages