GENERAL CLINICAL RESEARCH CENTER

洛杉矶县综合临床研究中心(GCRC) 港湾-加州大学洛杉矶分校医学中心(HUMC)现已进入第27个年头 手术。这项提案要求继续支持第28年的拨款 至32(1996年12月1日至2001年11月30日)，适用于住院单位(6张床位，1200张) 天)，门诊设施(4,000人次)，围产期临床研究 HUMC的PCRC中心(PCRC)，Martin Luther King-Drew Medical的卫星PCRC 中心(KDMC)(13,000个护理小时)和锡达斯西奈的卫星GCRC 医疗中心(CSMC)(33,059 GCRC工作小时)。当前应用程序 包括101项协议：其中79项将利用住院/门诊 HUMC的设施，22将使用HUMC和KDMC的临时数据中心，5将同时使用两者 GCRC和PCRC，44个协议将在CSMC使用GCRC。我们的 来自这三个地点的调查人员驻扎在 内科、儿科、妇产科、外科、精神病学 急诊医学、放射学和神经病学 次级专科，包括过敏/免疫学、心脏病学、内分泌学 新陈代谢、营养学、遗传学、血液学/肿瘤学、感染学 疾病，血液学，胃肠病学，重症监护医学，肺 医学、眼科学、泌尿学、药理学、卫生服务、医学 和放射科。我们GCRC的研究重点一直是男性生殖 慢性前列腺炎患者的内分泌学和避孕药发育及神经影像 药物滥用痴呆，睡眠神经内分泌学，精神生物学 种族、运动和成长、疾病的遗传基础(炎症性 肠道疾病、糖尿病、动脉粥样硬化)和肝脏支持 系统。为了满足我们调查人员的需求，并乘着 医疗改革，我们建议：1)扩大门诊量 活动；2)发展身体成分核心实验室；3)增加 KDMC的活动；以及4)建立保健服务研究服务 在CSMC的中心。这些战略发展将使我们能够提供核心 支持我们调查人员的多方面需求，包括高 密集的住院研究(例如，代谢、多次抽样、睡眠)， 大量门诊研究(例如，妇女健康倡议、糖尿病 拉美裔美国人的疾病)、围产期研究(例如，念珠菌的流行病学 母亲和新生儿的感染)，以及“保健结果”研究 与拟建的医疗服务研究中心合作。

The General Clinical Research Center (GCRC) at Los Angeles County Harbor-UCLA Medical Center (HUMC) is now in its twenty-seventh year of operation. This proposal requests continued support for grant year 28 through 32 (12/1/96 to 11/30/01) for an inpatient unit (6 beds, 1200 days), outpatient facilities (4,000 visits), a Perinatal Clinical Research Center (PCRC) at HUMC, a satellite PCRC at Martin Luther King-Drew Medical Center (KDMC) (13,000 nursing hours) and a satellite GCRC at Cedars Sinai Medical Center (CSMC) (33,059 GCRC staff hours). The current application includes 101 protocols: 79 of which will utilize inpatient/outpatient facilities at HUMC, 22 will use the PCRC at HUMC and KDMC, 5 will use both GCRC AND PCRCs, and forty-four protocols will use the GCRC at CSMC. Our investigators from the three sites are based in the Departments of Medicine, Pediatrics, Obstetrics/Gynecology, Surgery, Psychiatry, Emergency Medicine, Radiology and Neurology with a wide range of subspecialties, including Allergy/Immunology, Cardiology, Endocrinology and Metabolism, Nutrition, Genetics, Hematology/Oncology, Infectious Disease, Hematology, Gastroenterology, Critical Care Medicine, Pulmonary Medicine, Ophthalmology, Urology, Pharmacology, Health Services, Medicine and Radiology. Our GCRC's focus in research has been on male reproductive endocrinology and contraceptive development, neuroimaging of patients with dementia of drug abuse, neuroendocrinology of sleep, psychobiology of ethnicity, exercise and growth, genetic basis of diseases (inflammatory bowel disease, diabetes mellitus, atherosclerosis) and liver support systems. To meet the needs of our investigators and to ride the wave of health care reform, we are proposing: 1) to expand our outpatient activity; 2) develop a body composition core laboratory; 3) increase activity at KDMC; and 4) establish a health services research service center at CSMC. These strategic developments will allow us to provide core support for the multifaceted needs of our investigators including high intensity inpatient studies (e.g., metabolic, multiple sampling, sleep), high volume outpatient studies (e.g., Women's Health Initiative, Diabetes Mellitus in Hispanics), perinatal studies (e.g., epidemiology of candida infection in mothers and newborns), and "health care outcome" research with the proposed health services research center.