INTERACTION OF DRUGS W/ DNA TRIPLEXES

我们正在研究几种配体与短链DNA的相互作用。 考察序列、阳离子和碱的影响的三联体 修改。已经研究了几种类型的三联体，例如 具有由嘧啶或嘌呤组成的第三链或 鸟嘌呤和胸腺嘧啶的混合物。虽然我们大多数的嵌入者 研究人员可以结合这些三联体，他们倾向于结合而不是 复式公寓。MidasPlus在可视化类型方面非常有用 可以与三联体发生的相互作用。

We are studying the interaction of several ligands with short, DNA triplexes to examine the effect of sequence, cations and base modifications. Several types of triplexes have been examined, such as thos e with third strands composed of pyrimidines or purines or a mixture of guanine and thymine. While most of the intercalators we studied can bind to these triplexes, they tend to prefer binding to the duplexes. MidasPlus is of great utility in visualizing the types of interactions that can occur with triplexes.