APOE STATUS & HEALTH OUTCOMES IN OLDER PERSONS

这项研究将评估麦克阿瑟成功老龄化研究的参与者，以考察载脂蛋白E(ApoE)状态如何影响认知和身体衰退、心血管疾病发病率和死亡率以及在最初具有较高认知和身体功能的具有代表性的老年人样本中的全因死亡率。这些分析基于的证据表明，ApoE4基因型总体上与阿尔茨海默氏症、心血管疾病和寿命的风险增加有关，以及更具启发性的证据，即它可能还与认知能力下降和功能障碍的更普遍风险有关。麦克阿瑟成功老龄化队列的ApoE基因型数据是通过分析存储的DNA样本获得的。这些样本最初是在1988年研究开始时收集的。此前对采集的血液和尿样的分析包括胆固醇、脱氢表雄酮-S、糖化血红蛋白、同型半胱氨酸和叶酸水平以及尿皮质醇和儿茶酚胺的检测。此外，麦克阿瑟数据库中现有的信息包括社会人口、健康状况、健康行为、生理社会特征以及对身体和认知功能的详细评估。现已有8年后续行动期间(1988-1996年)的数据，包括关于认知和身体功能变化模式、心血管疾病的患病率和发病率以及总死亡率的详细信息。具有性别、种族、教育程度和行为特征(如个人健康行为(如锻炼、吸烟))的队列多样性也为拟议分析可能与这些特征相互作用的载脂蛋白E提供了足够数量的个人。-死亡率、认知功能、身体功能-人类受试者

This study will evaluate participants in the MacArthur Study on Successful Aging to examine how Apolipoprotein E (ApoE) status influences cognitive and physical decline, cardiovascular disease incidence and mortality, and all-cause mortality in a representative sample of older persons who initially had high cognitive and physical functioning. The analyses are based on evidence suggesting that ApoE4 genotype is associated with increased risk for Alzheimers disease, cardiovascular disease and longevity in general as well as more suggestive evidence that it may also be associated with more general risks for cognitive decline and functional disability.Data on ApoE genotype for the MacArthur Successful Aging cohort is being obtained through analyses of stored DNA samples. These samples were originally collected in 1988 at the beginning of the study. Previous analyses of collected blood and urine samples have included assays for cholesterol, DHEA-S, glycosylated hemoglobin, homocysteine and folic acid levels as well as urinary cortisol and catecholamines. Additional, existing information int he MacArthur database includes sociodemographic, health status, health behaviors, phychosocial characteristics and detailed assessments of both physical and cognitive functioning. Data are now available for an 8-year follow-up period (1988-1996), including detailed information on patterns of change in cognitive and physical functioning, prevalence and incidence of cardiovascular disease and overall mortality. Cohort diversity with repsect to gender, ethnicity, educational attainment and behavioral characteristics such as individuals health behaviors (e.g., exercise, smoking) also provides sufficient numbers of individuals for proposed analyses of possible ApoE interactions with these characteristics. - mortality, cognitive functioning, physical functioning - Human Subjects