CORE--DATA MANAGEMENT AND STATISTICS

数据管理和统计核心是满足所有统计和数据管理需求的中心资源。其他每个核心和研究项目产生的数据将转移到数据库部分，以便输入和存储在综合SIR/DBMS数据管理系统中，该系统旨在满足中心在清理、组织和检索数据以进行计划分析和临时分析方面的所有需要。这些活动将由一名数据管理员和一名数据录入员在核心主任的直接监督下在专门为数据管理操作配置的奔腾个人电脑联网系统上进行。核心管理部将继续每周与研究项目和其他核心部门的协调员和调查员举行会议，讨论所有与数据有关的问题，包括病人应计费用、数据完整性、检索和统计分析。统计部分将负责协调所有核心和项目调查人员进行的所有分析的规划和执行工作。拟议的研究项目具有某些共同特征，适用于类似的分析方法，包括粉碎的前瞻性队列、纵向数据收集、认知结果和关于随时间变化的假设，将使用生存分析进行分析。统计司核心将把1999年编入的约2 000名受试者纳入现有的WHICAP数据库系统，该系统现已包含原来的1992年编队。将开展这一进程，以便不仅可以容易地将来自原始群体和新群体的数据合并起来，用于两组的计划分析，而且还可以容易地区分和分开，以便进行针对群体的分析。与这两个小组合作，但也很容易区分和分开进行针对队列的分析。新闻部核心将与其他核心协作编写方案报告，以便利1999年组成员和原组幸存成员的年度后续行动，并将编写报告，向项目协调员提供联系每个主题所需的所有信息。

The Data Management and Statistics (DMS) Core constitutes the central resource for all statistical and data management needs. Data generated by each of the other cores and research projects will be transferred to the Database Component for entry and storage in an integrated SIR/DBMS data management system designed to meet all the needs of the Center with respect to cleaning, organization and retrieval of data for planned and ad hoc analyses. These activities will be carried out by a data manager and a data entry clerk working directly under the supervision of the Core director on a networked system of Pentium PCs specifically configured for data management operations. The DMS Core will continue to conduct weekly meetings with coordinators and investigators from the research projects and other cores to discuss all data-related issues, including patient accrual, data completeness, retrieval and statistical analysis. The Statistics Component will be responsible for coordinating the planning and implementation of all analyses conducted by investigators in all cores and projects. The proposed research projects have certain features in common that lend themselves to similar analytic methods, including a shred prospective cohort, collection of longitudinal data, cognitive outcomes and hypothesis regarding change over time that will be analyzed using survival analysis. The DMS Core will incorporate the estimated 2,000 subjects to be recruited in the 1999 cohort into the existing WHICAP data basing system, which now contains the original 1992 cohort. This process will be carried out so that data from the original cohort and the new cohort can not only be easily combined for planned analyzes of both groups, but also readily distinguished and separated for cohort-specific analyses. In collaboration with both groups, but also readily distinguished and separated for cohort- specific analyses. In collaboration with other cores, the DMS Core will develop programmed reports to facilitate annual follow up of members of the 1999 cohort as well as surviving members of the original cohort and will develop reports to provide the project coordinator with all information necessary to contact each subject.