NIEHS STATISTICAL CONSULTING SERVICE

该项目的目标是提供统计和计算专业知识的设计，分析和解释的实验结果的各种研究所的研究活动，包括实验室和人体研究。在1999财政年度，大约有80名科学家利用了统计咨询服务。其中许多活动涉及NTPs长期啮齿动物致癌性研究。在1999财政年度，我们为编写约12份总结这些研究结果的NTP技术报告提供了重要投入。我们还在科学文献中共同撰写了关于磁场、三氧化二钼、五氯苯酚和三氧化钼致癌作用的论文。其他合作的例子包括评估在Tg.AC转基因和p53杂合小鼠（两种在毒理学病理学中具有重要意义的遗传改变小鼠品系）的一组NTP研究中观察到的增殖性靶器官效应和对照肿瘤特征。- 统计咨询;合作研究;实验设计;数据分析;国家毒理学计划

The goal of this project is to provide statistical and computational expertise in the design, analysis, and interpretation of experimental results for a variety of Institute research activities, including both laboratory and human studies. Approximately 80 scientists made use of the Statistical Consulting Service in FY99. Many of these activities involved NTPs long term rodent carcinogenicity studies. During FY99 we provided significant input into the preparation of approximately 12 NTP Technical Reports that summarized the results of these studies. We also coauthored papers in the scientific literature dealing with the carcinogenic effects of magnetic fields, ethylbenzene, pentachlorophenol, and molybdenum trioxide. Examples of other collaborations include an assessment of the proliferative target organ effects and control tumor profiles observed in a set of NTP studies in Tg.AC transgenic and p53-heterozygous mice, two genetically altered mouse strains which are of emerging importance in toxicologic pathology. - Statistical consulting; collaborative research; experimental design; data analysis; National Toxicology Program