LINKAGE ANALYSIS OF PROSTATE CANCER

这项研究是对人类前列腺癌家系的连锁分析。该小组1996年在《科学》杂志上发表的一篇论文指出，前列腺癌的一个基因座可能与1号染色体的一个区域相连。X染色体上的第二个基因座已通过连锁分析与发表在《自然遗传学》，20：175-179(1998)上的结果进行了定位。继这些结果之后，今年对更多的家系与这些地区和其他地区的标记进行了密集的连锁分析，在最初的基因组扫描中显示了一些轻微的连锁证据。从美国、芬兰和瑞典的几个地区获得了家庭，并对其进行了基因分型。协会还对芬兰、冰岛和美国的数据进行了分析。为这个项目开发更多的家庭资源的努力也在进行中。这些研究人员还加入了一个国家前列腺癌连锁联盟，试图更快地定位前列腺癌基因座，该联盟的一篇荟萃分析论文描述了在一个非常大的组合数据集中与1号染色体基因座关联的证据，并提交了本财年发表。这项识别和克隆前列腺癌基因的项目正在进行中。-连锁、前列腺癌、图谱、易感性、基因-人类受试者

This study is a linkage analysis of families with human prostate cancer. A paper published in Science in 1996 by this group indicates the possibility of linkage of a locus for prostate cancer to a region of chromosome 1. A second locus on the X chromosome has been mapped by linkage analysis with results published in Nature Genetics, 20:175-179 (1998). These results have been followed up this year by intensive linkage analyses of additional families to markers in these regions and in other regions that showed some mild evidence of linkage in the initial genome scan. Families have been obtained and genotyped from several regions of the United States, Finland and Sweden. Association analyses have also been performed on data from Finland, Iceland and the U.S. Efforts are also underway to develop additional family resources for this project. These investigators have also joined a national Prostate Cancer Linkage Consortium to try to localize prostate cancer loci more rapidly, and a meta-analysis paper from this consortium describing the evidence for linkage to the chromosome 1 locus in a very large comnbined dataset was submitted for publication in this fiscal year. This project to identify and clone genes for prostate cancer is ongoing. - linkage, prostate cancer, mapping, susceptibility, gene - Human Subjects