STATISTICAL ANALYSIS OF GENETIC ANALYSIS WORKSHOP 11 DATA

该项目涉及对遗传分析研讨会11的两个数据集的分析。使用连锁和关联技术分析了COGA酒精中毒研究的一组数据，发现12号染色体上可能存在影响单胺氧化酶活性的基因座连锁的证据，并表明该基因座在吸烟者中可能比非吸烟者更重要。另一组数据是一个极其复杂的计算机模拟特性。比较了忽略和试图调整环境风险因素的几种分析方法。结果发现，主要增加的权力，在同胞对连锁分析，可以通过只分析暴露于危险因素的人，如果环境危险因素有相当大的影响，发病率。本财政年度已接受出版两份手稿。- 连锁分析，酒精中毒，模拟，样本容量

This project involved analysis of two datasets from the Genetic Analysis Workshop 11. A set of data from the COGA study of alcoholism was analyzed using linkage and association techniques, finding evidence for possible linkage on chromosome 12 of a locus influencing monoamine oxidase activity and showing that this locus may be more important in smokers than in non-smokers. Another set of data was for an extremely complex computer simulated trait. Several methods of analysis both ignoring and attempting to adjust for an environmental risk factor were compared. It was found that major increases in power in sib-pair linkage analyses can be obtained by analyzing only persons exposed to the risk factor, if the environmental risk factor has a fairly large effect on penetrance. Two manuscripts have been accepted for publication in this fiscal year. - linkage analysis, alcoholism, simulation, sample size