CORE--BIOSTATISTICS AND DATA MANAGEMENT

生物统计和数据管理核心(BDMC)的具体目标 1.维护派生自 临床核心，2.维护派生自 神经病理学核心，3.维护所有信息的数据集 源自亚洲发展研究中心的其他组成部分和附属项目，4. 要保持所有输入到 集中式数据库，5.协助开发数据收集 表格6.为项目、核心和项目提供统计咨询 与ADRC有关联的其他调查人员，7.例行提供数据 用于监测患者和控制受试者登记和流动的表格，8至 定期向管理核心提供数据摘要，以及 部分集中数据在需要时交给调查人员，以及9.至 执行ADRC核心和项目的统计分析。亚洲发展研究中心已经 购买了一台SUN 4/490计算机和用于数据管理的站点许可证 和统计软件包SAS，取代了以前使用的系统 DEC-10计算机上的M.U.M.P.S.编写了一个计算机程序 将数据从DEC-10存档到SUN 4/490。BDMC将创建一个 集中式数据管理系统使用SAS在SUN 4/490上接收， 存储、检索和分析从各种组件获得的数据 亚洲发展研究中心。该系统将为ADRC调查人员提供一种机制 访问与他们的研究工作相关的各种数据，并 确保知识产权的保密性和保护性。质量 控制程序，包括标准化表格、重复数据输入和 将进行定期审计，以确保所有信息的准确性 数据。已经为一些数据开发了标准化的表格。批准 执行委员会对所有手稿、赠款申请、 而使用亚洲发展研究中心资源的新项目将包括由BDMC进行审查，以 确保统计方法的正确使用和解释。 BDMC将为所有人提供生物统计咨询 使用ADRC资源的项目。

The specific aims of The Biostatistics and Data Management Core (BDMC) are: 1. To maintain data sets for all information derived from the Clinical Core, 2. To maintain data sets for all information derived from the Neuropathology Core, 3. To maintain data sets for all information derived from other ADRC components and from ADRC affiliated projects, 4. To maintain accuracy and confidentiality of all data entered into the centralized database, 5. To assist in the development of data collection forms, 6. To provide statistical consultation to projects, cores, and other investigators affiliated with the ADRC, 7. To routinely provide data tables to monitor patient and control subject enrollment and flow, 8. To provide periodic summaries of data to the Administrative Core, and portions of the centralized data to investigators when needed, and 9. To perform statistical analyses for ADRC cores and projects. The ADRC has purchased a SUN 4/490 computer and a site license for the data management and statistical package SAS, to replace the previous system which used M.U.M.P.S. on a DEC-10 computer. A computer program was written to archive data from the DEC-10 to the SUN 4/490. The BDMC will create a centralized data management system using SAS on the SUN 4/490 to receive, store, retrieve, and analyze data obtained from the various components of the ADRC. This system will provide a mechanism for ADRC investigators to access a variety of data relevant to their research endeavors, and to insure confidentiality and protection of intellectual property. Quality control procedures including standardized forms, double data entry, and regular audits will be put in place in order to insure accuracy of all data. Standardized forms have been developed for some data. The approval process by the Executive Committee for all manuscripts, grant submissions, and new projects using ADRC resources will include a review by the BDMC to insure the proper use and interpretation of statistical methods. Biostatistical consultation will be available from the BDMC for all projects using ADRC resources.