CORE--BIOSTATISTICS AND DATA MANAGEMENT

生物统计和数据管理核心（BDMC）的具体目标 是：1.为了维护从 临床核心，2。维护源自以下内容的所有信息的数据集 神经病理学核心，3。维护所有信息的数据集 来自其他ADRC组件和ADRC附属项目，4。 为确保所有输入的资料准确及保密， 中央数据库，5。协助开展数据收集工作 形式，6.为项目、核心和 其他调查员隶属于ADRC，7。定期提供数据 用于监测患者和对照受试者入组和流程的表格，8.到 定期向行政核心提供数据摘要，以及 在需要时向研究者提供部分集中数据，以及9.到 对ADRC核心和项目进行统计分析。 ADRC已 购买了一台SUN 4/490计算机和一个数据管理站点许可证 和统计软件包SAS，以取代以前的系统， M.U.M.P. S在DEC-10电脑上 一个计算机程序被编写成 从DEC-10到SUN 4/490的存档数据。 BDMC将创建一个 集中式数据管理系统采用SAS对SUN 4/490进行接收， 存储、检索和分析从各种组件获得的数据， ADRC。 该系统将为ADRC调查人员提供一种机制， 访问与其研究工作相关的各种数据，并 确保机密性和知识产权保护。 质量 控制程序，包括标准化表格，双重数据输入， 定期审计将到位，以确保所有的准确性， 数据 已为一些数据编制了标准化表格。 批准 执行委员会对所有手稿，赠款申请， 使用ADRC资源的新项目将包括BDMC的审查， 确保正确使用和解释统计方法。 生物统计咨询将从BDMC提供给所有 利用ADRC资源。

The specific aims of The Biostatistics and Data Management Core (BDMC) are: 1. To maintain data sets for all information derived from the Clinical Core, 2. To maintain data sets for all information derived from the Neuropathology Core, 3. To maintain data sets for all information derived from other ADRC components and from ADRC affiliated projects, 4. To maintain accuracy and confidentiality of all data entered into the centralized database, 5. To assist in the development of data collection forms, 6. To provide statistical consultation to projects, cores, and other investigators affiliated with the ADRC, 7. To routinely provide data tables to monitor patient and control subject enrollment and flow, 8. To provide periodic summaries of data to the Administrative Core, and portions of the centralized data to investigators when needed, and 9. To perform statistical analyses for ADRC cores and projects. The ADRC has purchased a SUN 4/490 computer and a site license for the data management and statistical package SAS, to replace the previous system which used M.U.M.P.S. on a DEC-10 computer. A computer program was written to archive data from the DEC-10 to the SUN 4/490. The BDMC will create a centralized data management system using SAS on the SUN 4/490 to receive, store, retrieve, and analyze data obtained from the various components of the ADRC. This system will provide a mechanism for ADRC investigators to access a variety of data relevant to their research endeavors, and to insure confidentiality and protection of intellectual property. Quality control procedures including standardized forms, double data entry, and regular audits will be put in place in order to insure accuracy of all data. Standardized forms have been developed for some data. The approval process by the Executive Committee for all manuscripts, grant submissions, and new projects using ADRC resources will include a review by the BDMC to insure the proper use and interpretation of statistical methods. Biostatistical consultation will be available from the BDMC for all projects using ADRC resources.