DRUG EXCRETION IN TRANSPLANT PATIENTS
DRUG EXCRETION IN TRANSPLANT PATIENTS
批准号:
6219259
负责人:
Raman Venkataramanan
金额:
$0.3万
依托单位国家:
美国
项目类别:
财政年份:
1998
资助国家:
美国
项目状态:
已结题
起止时间:
1998-12-01 至 1999-11-30
关键词:
biomarker blood chemistry cephalosporins clinical research clinical trials drug metabolism glomerular filtration halobenzene human subject ion transport kidney disorder diagnosis kidney function kidney pharmacology kidney transplantation p aminohippurate postoperative state renal tubular transport urinalysis
中文摘要
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英文摘要
The objective of this study is to access renal function in renal transplant patients. Here kidney function is determined by administering renal markers--PAH, Iothalamate and Cephalexin to renal transplant patients to study active tubular anionic secretion, filtration, and active tubular secretion. 12 kidney transplant patients will be divided into 2 groups, 6 will receive Iothalamate and PAH over a 3 hour period, the other 6 will receive Cephalexin as a bolus and studied over 8 hrs. Drugs will be assayed in plasma and urine collected, and results compared with/6 normals receiving Ioth/PAH.
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