LASER MICRO-BEAM CT SCANNING OF DOSIMETRY GELS

描述(申请人摘要逐字)：本项目的长期目标 是为放射治疗部门和设备供应商提供独一无二的 用于准确、快速和完全三维地表征小型 具有各向同性的放射治疗领域，无论是外照射还是近距离照射 空间分辨率约为100微米。我们的系统是基于激光的 组织等效剂量计凝胶的微束CT扫描 光学性质与吸收剂量成正比。在第一阶段，我们有 设计、建造并彻底测试了两种不同的原型 微型扫描仪，并成功地证明了我们的想法的可行性。在……里面 第二阶段，我们将完成微型扫描仪的研发和 将设计出各种凝胶模体进行微扫描。我们将实地测试我们的 系统在临床环境中，并执行彻底的剂量学研究 各种临床重要的小范围和近距离放射治疗来源， 将我们的技术与辐射变色胶片测量进行比较。在第三阶段，我们 将授权制造我们的微型扫描仪，并集中我们的 制造用于高分辨率3D的各种凝胶剂量学模体的努力 剂量学。我们相信，我们的系统将在质量保证程序中得到广泛应用 在患者治疗验证中，无论剂量梯度非常高 出现在治疗计划中。 建议的商业应用： 不可用

DESCRIPTION (Applicant's abstract verbatim): The long-term goal of this project is to provide radiation therapy departments and equipment vendors with a unique tool for accurate, fast and fully three-dimensional characterization of small radiotherapy fields, whether external beams or brachytherapy, with isotropic spatial resolution on the order of 100 microns. Our system is based on laser micro-beam CT scanning of tissue-equivalent dosimeter gels that change their optical properties in proportion to the absorbed dose. In Phase I we have designed, built and thoroughly tested two different prototypes of the micro-scanner, and have successfully proved the feasibility of our idea. In Phase II we will complete the research and development of the micro-scanner and will engineer various gel phantoms for micro-scanning. We will field-test our system in a clinical environment, and perform thorough dosimetry studies of various small fields and brachytherapy sources of clinical importance, comparing our technique with radiochromic film measurements. In Phase III we will license out the manufacture of our micro-scanner, and concentrate our efforts on manufacturing various gel dosimetry phantoms for high-resolution 3D dosimetry. We believe that our system will find widespread use in QA procedures and in patient treatment verification, wherever very high dose gradients are present in the treatment plan. PROPOSED COMMERCIAL APPLICATION: Not Available