TISSUE PERFUSION AND BLOOD FLOW MONITORING TECHNOLOGY

目的是开发一种用于测量皮肤血流速度的实时光学成像装置。在第一阶段，开发了获取数字化血液速度的技术，以监测感兴趣的区域，并在动物模型上证明了初步原型的准确性。第二阶段的具体目标包括开发先进的原型，改进第一阶段开发的算法，临床研究，设备的评估和验证，以及在第三阶段开发商业设备的关键工程问题的调查。先进的原型和算法的评估和验证将进行静态和动态散斑，猪模型和人类受试者的测量。潜在的创新包括开发一种用于非接触式实时监测组织灌注的集成设备，以及开发血液和组织光学和光学成像的先进算法。使用该技术检测组织血管结构的变化提供了对患者进行定期、安全和常规监测的手段。该技术在评估外科手术，如皮瓣，血管疾病的治疗，糖尿病并发症的状况，肿瘤的进展和移植手术器官的状况方面具有潜力。拟定商业应用：新设备将提供实时、非接触、区域成像能力，而不是激光多普勒流量计提供的点测量。商业应用包括在涉及皮瓣、手指再附着、移植和血管手术的整形和重建手术期间和之后以及在创伤治疗过程期间监测患者的组织活力。

The objective is to develop a real-time, optical imaging device for measuring skin blood flow velocities. In Phase I, the technology of acquiring digitized blood velocities was developed to monitor areas of interest and the accuracy of a preliminary prototype was demonstrated animal models. Specific aims of Phase II include the development of an advanced prototype, improvement of algorithms developed in Phase I, a clinical study, evaluation and validation of the device, and an investigation of critical engineering issues for developing the commercial device in Phase III. Evaluation and validation of the advanced prototype and algorithms will be conducted on measurements of static and dynamic speckle, a porcine model, and human subjects. Potential innovations include the development of an integrated device for noncontact, real-time monitoring of tissue perfusion and the development of advanced algoriths of blood and tissue optics and optical imaging. Detection of changes in tissue vascular structure using this technology offers a means for regular, safe, and routine monitoring of patients. This technology has potential in assessing surgical procedures such as flaps, the treatment of vascular disease, the condition of diabetic complications, the progression of tumors and the condition of organs for transplant surgery. PROPOSED COMMERCIAL APPLICATION: The new device will provide real-time, noncontact, area imaging capabilities rather than point measurements as provided by laser Doppler flowmeters. Commercial applications include monitoring tissue viability for patients during and after plastic and reconstructive surgery involving flaps, digit reattachment, transplants, and vascular surgery, and during trauma treatment procedures.