Digital Resolution Improvement of SLO Angiograms

描述(由申请人提供)：此项目的主要商业目标 Research是为视网膜专家提供的有利可图的软件产品，它将 提供改进的血管系统和其他结构的2D分辨率 眼底，使用荧光染料与扫描激光眼底镜(SLO)。 这些染料是吲哚青绿(ICG)，它是红外线，因此可以显示 深层结构，如脉络膜和视神经血管，以及荧光素 (FITC)，它在可见光光谱中，从而显示视网膜 维管系统(顶层)。仅在SLO血管造影术方面，我们就看到了一个有利可图的市场。 我们的专业知识和现有的销售渠道都在这个市场上。一个同样大的 传统的数字眼底照相存在市场。这件事的重点是 第二阶段项目将是SLO血管造影术。这项工作将在稍后应用，因为 数字眼底摄影和反射光SLO(如 海德堡视网膜断层扫描仪)。这项第二阶段研究的目标是 旨在提炼和证明方法论，开启广阔的医学研究 和临床客户群。具体目标是：(1)提高速度 接近常规临床实践所需的执行时间；(2)确保 对各种数据类型和条件的健壮性；(3)开发变种 提供亚像素分辨率的方法。(4)展示两个 医疗研究和临床实用，将激发广泛的兴趣 视网膜专家客户群-从事医学研究和 临床实践。 建议的商业应用： 该产品最初将是几家制造商(Heidelberg， 罗登斯托克(Rodenstock，LDT)，并最终成为数字眼底相机的附件。这里有大约 每年1000个新的SLO站点，当考虑到所有模式时，这个数字是 戏剧性地增长。价格将在1000美元左右。

DESCRIPTION (provided by applicant): The primary commercial objective of this research is a profitable software product for retinal specialists that will provide improved 2D resolving power of vasculature and other structures in the fundus, using fluorescent dyes with the scanning laser ophthalmoscope (SLO). These dyes are indocyanine green (ICG), which is infrared and thereby displays deep structures such as choroidal and optic nerve vasculature, and fluorescein (FITC) which is in the visible light spectrum and thereby displays retinal vasculature (top layer). We see a profitable market in SLO angiography alone. Our expertise and existing sales channels are in this market. An equally large market exists in conventional digital fundus photography. The focus of this Phase 2 project will be on SLO angiography. The work will later be applied, as well, to digital fundus photography and the reflected light SLO (such as the Heidelberg Retinal Tomograph). The objectives of this Phase II research are aimed at refining and proving the methodology to open a broad medical-research and clinical customer base. The specific aims are to: (1) Improve the speed to approach execution times necessary for routine clinical practice; (2) Ensure robustness with a variety of data types and conditions; (3) Develop a variant of the method that provides subpixel resolving power. (4) Demonstrate both a medical-research and clinical utility that will excite the interest of a broad customer base of retinal-specialist customers who are in medical-research and clinical practice. PROPOSED COMMERCIAL APPLICATION: The product will initially be an add-on to SLO's from several manufactures (Heidelberg, Rodenstock, LDT) and eventually an add-on to digital fundus cameras. There are about 1000 new SLO sites per year, when all modalities are considered, and this number is growing dramatically. The price will be about $1000.