Applying Exercise Intervention to Drug Treatment

描述：(申请人提供) 对药物依赖患者增加运动的干预代表着一种 预防复发的潜在有用但尚未探索的策略。确实有 目前还没有针对这一人群的既定运动干预措施。 这项研究计划的长期目标是改善治疗。 通过开发和建立疗效为药物依赖患者提供选择 在监督下进行有氧运动干预，并增进对 体力活动与物质使用结果之间的关系。 在目前的应用中，我们建议开发一种有监督的有氧运动 (SAE)对药物依赖患者进行干预并进行初步的， 随机临床试验，检查其疗效并与简要的 建议(BA)运动干预。在这个项目的第一阶段(第一年)， 我们将开发和试点SAE干预，有20名患者完成 白天和晚上密集的酒精和药物治疗计划。我们还将 开发一个行为组件来促进锻炼的坚持，包括 临床医生和病人手册。在第二阶段(第二年和第三年)，我们将 对50名久坐不动的药物依赖者进行初步随机试验 患者检查SAE干预相对于BA的疗效 在六个月的随访期内比较情况。 我们预计，相对于BA情况，参与者被随机分配到 SAE状况将显示出更好的药物使用结果 改善情绪、抑郁症状和心肺健康。如果 这种干预的有效性可以在这项试验中和在 随后的临床试验，将为药物依赖患者提供 传统药物滥用治疗的有价值的辅助或替代方法。

DESCRIPTION: (provided by applicant) Intervention to increase exercise in drug dependent patients represents a potentially useful yet unexplored strategy for preventing relapse. There are currently no established exercise interventions for use with this population. The long-term objectives of this research program are to improve treatment options for drug dependent patients by developing and establishing the efficacy of a supervised aerobic exercise intervention and to advance knowledge of the relationship between physical activity and substance use outcomes. In the present application, we propose to develop a supervised aerobic exercise (SAE) intervention for drug dependent patients and to conduct a preliminary, randomized clinical trial, examining its efficacy in comparison to a brief advice (BA) exercise intervention. In the first phase of this project (Year 1), we will develop and pilot the SAE intervention with 20 patients completing an intensive day and evening alcohol and drug treatment program. We will also develop a behavioral component to promote exercise adherence, including clinician and patient manuals. In the second phase (Years 2 & 3) we will conduct a preliminary, randomized trial with 50 sedentary drug dependent patients to examine the efficacy of the SAE intervention relative to the BA comparison condition over a six-month follow-up period. We expect that, relative to the BA condition, participants randomized to the SAE condition will demonstrate better substance use outcomes as well as improved mood, depressive symptoms, and cardiorespiratory fitness. If the efficacy of this intervention can be established in this trial and in subsequent clinical trials, drug dependent patients will be provided with a valuable adjunct or alternative to traditional substance abuse treatment.