CARDIAC METABOLISM & FLOW

要完成的工作包括1.一系列研究 表征心脏微血管形态的异质性和 区域血流，使用形态测量技术结合 基于微球的局部流动测量，使用新的分形 用自相关技术确定信号的方向性 局部流动之间的相关性，并确定流动的非均质性 大心脏的高空间分辨率。2.中国的发展 解释15O氧信号的分析方法， 15O-水和15O-一氧化碳残基功能(通过PET成像) 心脏中的氧含量和估算局部血氧的方法 来自这些心脏的消耗并显示这些 表现为局部氧代谢率、血管容量和 渗透率-表面积产品。3.一系列研究，以 确定增加的心肌代谢是否降低了 控制期间绵羊心脏整体血流的不均一性 状态、肾上腺素能刺激和心房起搏。这项研究，在 在领导下与PET成像研究合作 需要放射性同位素方面的服务支持 化学，PET成像物理学(设备维护和 软件开发)和成像过程，所有这些都在 与核医学和放射学人员合作。4. 为研究提供放射化学、PET物理和成像支持 心脏代谢和血流(HL50238)与心肌氧合 (HL52039)。

The work to be accomplished encompasses 1. A series of studies to characterize heterogeneities in cardiac microvascular form and regional blood flows, using morphonetric techniques combined with microsphere-based measures of local flow, using new fractal autocorrelation techniques to determine the directionality of the correlations among local flows, and determining flow heterogeneity at high spatial resolution in large hearts. 2. The development of methods of analysis for interpreting signals from 15O-oxygen, 15O-water, and 15O-carbon monoxide residue functions (by PET imaging) in the heart and the methods for estimating regional oxygen consumption from these hearts and displaying parametric images of such features as local oxygen metabolic rate, vascular volumes, and permeability-surface area products. 3. A series of studies to determine if increased myocardial metabolism reduces the degree of flow heterogeneity in the heart overall in sheep during control states, adrenergic stimulation and atrial pacing. This research, in collaboration with PET imaging studies performed under the leadership of James H. Caldwell requires service support in radioisotope chemistry, in physics of PET imaging (equipment maintenance and software development) and in imaging procedures, all of which are in collaboration with personnel in Nuclear Medicine and Radiology. 4. To provide radiochemistry, PET physics and imaging support for studies of cardiac metabolism and flow (HL50238) and myocardial oxygenation (HL52039).