Psychosocial and Ethical Literature in Cancer Genetics

这项申请建议编写一本关于最新的心理社会研究和伦理写作的权威书籍，以及与癌症遗传学和癌症基因测试有关的政策。在人类基因组伦理、法律和社会影响计划启动十年后，以及癌症遗传学现代时代的开始，这本书将总结和批评现有的社会科学和医学文献，试图回答关于基因技术对人类影响的重要问题。遗传学的进步有望促使医学实践发生根本性变化。基因技术的进步导致了癌症风险评估的新方法。在接下来的几十年里，关于疾病易感性的遗传本质的信息将会爆炸式增长。从一开始，人类基因组计划就认识到了解码人类基因组的巨大社会后果。早期迹象有力地表明，心理社会因素在对基因技术的态度和利用方面发挥着重要作用。社会科学研究可以提供关于哪些方面的数据 将干预措施的开发作为基础，以最大限度地发挥基因研究的好处。然而，至关重要的是，这种干预措施还应考虑到人类使用基因技术的伦理方面。这个项目的目标是1。)从广泛的社会科学和遗传学学科中总结和评论与癌症基因检测的心理社会和伦理方面有关的文献，2.使心理社会领域和伦理领域 癌症遗传学的各个方面对新的/年轻的社会科学研究人员来说更容易接近，3)3.建立联系并鼓励从事基因测试工作的社会科学家和具有相关相关领域专业的社会科学家之间的未来合作研究。鼓励认识国际社会科学家在癌症基因检测的心理社会方面的工作，以及5.)通过提供以下服务，鼓励将心理社会研究成果转化为癌症遗传学项目的发展 心理社会和伦理文献的可访问摘要，供正在建立癌症遗传学计划的医学和遗传学专业人员使用。

This application proposes the preparation of a definitive book on state-of-theart psychosocial research and ethical writing and policy relating to cancer genetics and genetic testing for cancer genes. One decade after the initiation of the Ethical, Legal, and Social Implications Program of the Human Genome and the start of the modern era in cancer genetics, this book will summarize and critique existing social science and medical literature to try to answer important questions about the human impact of genetic technology. Advances in genetics promise to catalyze a fundamental change in the practice of medicine. Genetic advances have led to new approaches to the assessment of cancer risk. The coming decades will see an explosion of information about the hereditary nature of disease susceptibility. From its inception, the Human Genome Project has recognized the enormous social ramifications of decoding the human genome. Early indications are strong that psychosocial factors play a major role in attitudes towards and utilization of genetic technology. Social science research can provide data on which to base development of interventions to maximize the benefits of genetic research. It is crucial, however, that such interventions consider also the ethical aspects of human use of genetic technology. The goals of this project are 1. ) To summarize and critique the literature from a broad spectrum of social science and genetic disciplines related to psychosocial and ethical aspects of cancer genetic testing, 2.) To make the area of psychosocial and ethical aspects of cancer genetics more approachable to new/young social science investigators, 3.) To create links and encourage future collaborative research between social scientists working in genetic testing and social scientists with specialties in relevant related areas, 4.) To encourage awareness of the work of international social scientists with regard to psychosocial aspects of cancer genetic testing, and 5.) To encourage translational integration of psychosocial research findings into the development of cancer genetics programs through the provision of accessible summaries of psychosocial and ethical literature for use by medical and genetic professionals who are establishing cancer genetics programs.