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REGULATION OF HUMAN IGH GENE LOCUS BY 3 ENHANCERS

REGULATION OF HUMAN IGH GENE LOCUS BY 3 ENHANCERS
3 个增强子对人类 IGH 基因座的调节
批准号：
6373659
负责人：
Barbara Birshtein
金额：
$17.22万
依托单位：
ALBERT EINSTEIN COLLEGE OF MEDICINE
依托单位国家：
美国
项目类别：
财政年份：
1997
资助国家：
美国
项目状态：
已结题
起止时间：
1997-09-15 至 2003-08-31
来源：
https://reporter.nih.gov/project-details/6373659
关键词：
animal genetic material tag gene expression gene rearrangement genetic enhancer element genetic mapping genetic regulation human genetic material tag immunoglobulin genes molecular cloning nucleic acid probes tissue /cell culture transcription factor

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中文摘要
翻译
研究小组已经克服了一些克隆障碍，并已经 成功确定了两个几乎相同的增强剂，其中一个位于 两个人类Cα基因各约10kb的3‘。 这些增强子含有与小鼠同源的191个碱基片段 增强子3‘AE(HST2)。他们希望研究人类的调节 Cα相关增强子，以进一步映射这些下游 地区，并评估他们的其他增强剂，他们预测 以及影响免疫球蛋白基因的获得性变异 在正常、免疫缺陷和恶性状态下的表达。
英文摘要
The investigator's group has surmounted some cloning barriers and has succeeded in identifying two virtually identical enhancers, one located approximately 10 kb 3' of each of the two human C alpha genes. These enhancers contain a 191 bp segment of homology to the murine enhancer 3'aE (Hst2). They wish to study the regulation of the human C alpha associated enhancers, to further map these downstream regions and assess them for additional enhancers which they predict to be present, and to acquired variations that influence IgH gene expression in normal, immunodeficient and malignant states.
期刊论文(4)
专著(0)
科研奖励(0)
会议论文
Comparative analysis of human and mouse 3' Igh regulatory regions identifies distinctive structural features.
对人和小鼠 3 Igh 调节区的比较分析确定了独特的结构特征。
DOI： 10.1016/j.molimm.2004.09.006
发表时间： 2005
期刊： Molecular immunology
影响因子： 3.6
作者： [Sepulveda,ManuelA, Garrett,FrancineE, Price-Whelan,Alexa, Birshtein,BarbaraK]
通讯作者： Birshtein,BarbaraK
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Bronx Einstein Training in Teaching and Research (BETTR)
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Bronx-Einstein Training in Teaching and Research (BETTR), an IRACDA program
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