HEALTH HAZARDS FROM GROUNDWATER CONTAMINATION

请支持继续开展面向人类健康的研究，研究接触超级基金场址常见化学品的风险，以及研究新的清理技术，以消除接触这些场址化学品的可能性。正在调查的污染物包括污染地下水的相对水溶性化学物质，如三氯乙烯和环境持久性脂溶性化学物质，如多氯联苯和多环芳烃。提出了一个高度整合的多学科研究计划，包括9个研究项目和4个支持核心单元。由24名研究人员组成的研究团队包括9个研究项目和4个支持核心单位的教师。由24名调查人员组成的研究小组包括密歇根州立大学（12人）、密歇根大学（8人）、斯坦福大学（2人）、罗格斯大学（1人）和橡树岭国家实验室（1人）的教师。研究的重点在四个方面：1)了解控制环境持久性和污染物对参与生物降解的微生物的生物利用度的因素的机制，3)确定有目的地改变（工程）地下环境对生物降解速率的有效性，4)评估环境产生的化学产品对生物降解速率的影响，4)评估生物修复产生的化学产品的毒性潜力。3)确定有目的地改变（工程）地下环境对生物降解速率的有效性；4)评价生物修复产生的化学产品对生物降解速率的影响；4)评价生物修复产生的化学产品的毒性潜力。生物医学研究项目包括多氯联苯对免疫毒性的影响，生殖和发育毒性，以及发育神经毒性，场地修复研究包括地下水污染物的生殖生物修复，新型大化学物质的合成和开发参与化学物质的保留参与化学物质在含有卤化溶剂和金属的地下水中的保留，研究控制地下水和土壤生物修复速率的因素。一个核心实验室将协调测试多氯联苯和混合废物中常见的其他污染物生物降解产生的中间和最终产品。该测试将允许修改实验性修复过程，以最大限度地解毒在环境中发现的有毒混合物。博士后培训计划将包括交叉培训经验，以提高近期博士毕业生在多学科研究团队中的能力。一个外联核心将与设在密歇根大学的环境保护署有害物质研究中心的社区援助部门合作，制作信息材料，用于与受到接触有害化学品威胁影响的社区合作。

Support is requested to continue human health-oriented research on risks from exposure to chemicals commonly found in Superfund sites and on new clean-up technologies to eliminate the potential for exposure to chemicals from thos3e sites. The pollutants under investigation include relatively water soluble chemicals that contaminate groundwater such as trichloroethylene and environmentally persistent lipid soluble chemicals such as PCBs and PAHs. A highly integrated, multi-disciplinary research program is proposed consisting of nine research projects and four supporting core units. The research team of 24 investigators include faculty at nine research projects and four supporting core units. The research team of 24 investigators include faculty at Michigan State University (12), The University of Michigan (8), Stanford (2), Rutgers (1) ant the Oak Ridge National Laboratory (1). The major thrusts of the research are in four areas: 1) understanding the mechanisms of factors controlling the environmental persistence and bioavailability of contaminants to microbes involved in biodegradation, 3) determination of the effectiveness of purposefully altered (engineered) subsurface environments on the rates of biodegradation and 4) evaluation of chemical products produced from environments on the rates of biodegradation and 4) evaluation of chemical products produced from bioremediation for toxicity potential, 3) determination of the effectiveness of purposefully altered (engineered) subsurface environments on the rates of biodegradation and 4) evaluation of chemical products produced from bioremediation on the rate of biodegradation and 4) evaluation of chemical products produced from bioremediation for toxicity potential. The research projects classified as biomedical include studies examining the effects of PCBs to cause immunotoxicity, reproductive and developmental toxicity, and developmental neurotoxicity, Site remediation research includes reproductive bioremediation of groundwater contaminants, the synthesis and development of novel macrochemical to participate in retention of chemicals to participate in retention of chemicals in groundwater plumes containing halogenated solvents and metals, and an examination of factors that control the rate of groundwater and soil bioremediation. A core laboratory will coordinate the testing of the intermediate and end products generated from biodegradation of PCBs and other contaminants commonly found in mixed waste. This testing will permit modification of experimental remediation processes to maximize the detoxification of toxic mixtures found in the environment. A postdoctoral training program will involve cross training experiences to improve the ability of recent Ph.D. graduates to perform in multi-disciplinary research teams. An Outreach Core will partner with the community assistance component of an EPA Hazardous Substance Research Center at the University of Michigan to produce information materials for use in working with communities impacted by the threat of exposure to hazardous chemicals.