FLUORESCENCE CORRELATION SPECTROSCOPY IN MICROSCALE FLUID JETS
FLUORESCENCE CORRELATION SPECTROSCOPY IN MICROSCALE FLUID JETS
批准号:
6349431
负责人:
JONAS KORLACH
金额:
$1.44万
依托单位:
依托单位国家:
美国
项目类别:
财政年份:
2000
资助国家:
美国
项目状态:
已结题
起止时间:
2000-09-01 至 2001-08-31
中文摘要
阿尔茨海默病的特征是
细胞外淀粉样沉积物和细胞内神经胶质细胞
最近,转基因小鼠已经被改造,
淀粉样蛋白以年龄依赖的方式沉积。 在这次合作中
我们用多光子显微镜观察活体转基因小鼠,
研究体内淀粉样蛋白沉积的动力学,
沉积的淀粉样蛋白在体内被清除的假设,
监测斑块沉积物和斑块附近的氧化应激水平
丹
英文摘要
Alzheimer's Disease is distinguished by the accumulation of
extracellular amyloid deposits and intracellular neurofibrillary
tangles; recently transgenic mice have been engineered that develop
amyloid deposits in an age-dependent fashion. In this collaboration
we use multiphoton microscopy on living transgenic mice to visualize
and study the in vivo kinetics of amyloid deposition, to test directly
the hypothesis that deposited amyloid is cleared in vivo, and to
monitor the level of oxidative stress near plaque deposits and plaque
cores.
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会议论文
Picogram-level DNA sequencing using Nanopores and Zero-Mode Waveguides
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批准号:8545204
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项目类别:
-
资助金额:$27.88万
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财政年份:2012
-
负责人:JONAS KORLACH
-
依托单位:
Picogram-level DNA sequencing using Nanopores and Zero-Mode Waveguides
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批准号:8361479
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项目类别:
-
资助金额:$30.22万
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财政年份:2012
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负责人:JONAS KORLACH
-
依托单位:
Picogram-level DNA sequencing using Nanopores and Zero-Mode Waveguides
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批准号:8715843
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项目类别:
-
资助金额:$23.12万
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财政年份:2012
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负责人:JONAS KORLACH
-
依托单位:
Direct Real-Time Transcriptome Sequencing
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批准号:7926894
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项目类别:
-
资助金额:$197.08万
-
财政年份:2010
-
负责人:JONAS KORLACH
-
依托单位:
SYNTHESIS OF NEW CLASS OF DEOXYNUCLEOTIDE ANALOGS
-
批准号:6349399
-
项目类别:
-
资助金额:$1.73万
-
财政年份:2000
-
负责人:JONAS KORLACH
-
依托单位:
OBSERVATION OF REAL TIME SYNTHESIS OF INDIVIDUAL DNA MOLECULES
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批准号:6349401
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项目类别:
-
资助金额:$4.33万
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财政年份:2000
-
负责人:JONAS KORLACH
-
依托单位:
CONSULTATION:
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批准号:6349496
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项目类别:
-
资助金额:$0.01万
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财政年份:2000
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负责人:JONAS KORLACH
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依托单位:
FLUORESCENCE CORRELATION SPECTROSCOPY IN CLOSED NANOSTRUCTURED FLUID CHANNELS
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批准号:6349432
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项目类别:
-
资助金额:$1.38万
-
财政年份:2000
-
负责人:JONAS KORLACH
-
依托单位:
FLUORESCENCE CORRELATION SPECT W/ SINGLE MOLEC SENSITIV ON CELL & MODEL MEMBRANE
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批准号:6349398
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项目类别:
-
资助金额:$2.13万
-
财政年份:2000
-
负责人:JONAS KORLACH
-
依托单位:
ANALYSIS OF SINGLE FLUORESCENT MOLECULES TRAPPED INSIDE SMALL LIPID VESICLES
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批准号:6349400
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项目类别:
-
资助金额:$1.47万
-
财政年份:2000
-
负责人:JONAS KORLACH
-
依托单位:
ANOMALOUS SUBDIFFUSION OF PROTEINS & LIPIDS IN MEMBRANES: FLUORESCENCE SPECT
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批准号:6349493
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项目类别:
-
资助金额:$0.06万
-
财政年份:2000
-
负责人:JONAS KORLACH
-
依托单位:
COMMUNICATIONS
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批准号:6349497
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项目类别:
-
资助金额:$0.03万
-
财政年份:2000
-
负责人:JONAS KORLACH
-
依托单位:
CELL & MODEL MEMBRANES BY CONFOCAL MICROSCOPY & FLUORESCENCE CORRELATION SPECT
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批准号:6349494
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项目类别:
-
资助金额:$0.06万
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财政年份:2000
-
负责人:JONAS KORLACH
-
依托单位:
LIPID BILAYER PHASES BY CONFOCAL MICROSCOPY & FLUORESCENCE CORRELATION SPECT
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批准号:6349430
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项目类别:
-
资助金额:$1.06万
-
财政年份:2000
-
负责人:JONAS KORLACH
-
依托单位:
FLUORESCENCE CORRELATION SPECT & SINGLE MOLECULE DETECTION
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批准号:6349495
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项目类别:
-
资助金额:$0.11万
-
财政年份:2000
-
负责人:JONAS KORLACH
-
依托单位:
CELL & MODEL MEMBRANES BY CONFOCAL MICROSCOPY & FLUORESCENCE CORRELATION SPECT
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批准号:6206228
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项目类别:
-
资助金额:$0.06万
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财政年份:1999
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负责人:JONAS KORLACH
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依托单位:
FLUORESCENCE CORRELATION SPECT & SINGLE MOLECULE DETECTION
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批准号:6206229
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项目类别:
-
资助金额:$0.11万
-
财政年份:1999
-
负责人:JONAS KORLACH
-
依托单位:
FLUORESCENCE CORRELATION SPECT W/ SINGLE MOLEC SENSITIV ON CELL & MODEL MEMBRANE
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批准号:6206132
-
项目类别:
-
资助金额:$2.13万
-
财政年份:1999
-
负责人:JONAS KORLACH
-
依托单位:
SYNTHESIS OF NEW CLASS OF DEOXYNUCLEOTIDE ANALOGS
-
批准号:6206133
-
项目类别:
-
资助金额:$1.73万
-
财政年份:1999
-
负责人:JONAS KORLACH
-
依托单位:
ANALYSIS OF SINGLE FLUORESCENT MOLECULES TRAPPED INSIDE SMALL LIPID VESICLES
-
批准号:6206134
-
项目类别:
-
资助金额:$1.47万
-
财政年份:1999
-
负责人:JONAS KORLACH
-
依托单位:
海外基金