CONSTRUCTION OF RHESUS MACAQUE FACILITY

描述（由申请人提供）：拟议的建设将提供一个复杂的六个建筑物用于SPF印度原产恒河猴和使用它们在艾滋病相关的研究。 繁殖设施将由四座建筑物组成，每座建筑物有14个室内-室外笼子。 这些建筑的总面积为14，864平方英尺。 饲养笼被分隔成四个建筑物，以减少疾病传播。 气候控制建筑（544平方米）（英尺）将与用于治疗患病动物的饲养笼建筑密切相关。 它将有一个治疗室，一个隔离室和支持室。 建筑群内的其余建筑物将作为人员支助设施。 它将包括两个更衣室，一个办公室和一个休息室（624平方米）。ft.）。 在这个综合体中饲养的SPF繁殖群由美国国立卫生研究院（NIH）合作协议（U42-RR 16024）资助。 根据这项合作协议，西南研究中心将生产SPF恒河猴，主要供美国国立卫生研究院的受资助者进行艾滋病相关研究。 SWRPRC繁殖群目前由大约290只动物组成，被安置在距离SWRPRC约20英里的一个40年历史的综合体中，并位于一个军事基地上，该基地计划于2002年移交给圣安东尼奥市。 除了从远处维持这样一个设施的操作困难之外，目前的设施无法容纳预期在今后四年内大约增加一倍的蜂群规模。 SWRPRC结合了经验丰富的专业人员，成熟的方法和优良的设施，用于猴免疫缺陷病毒（SIV）/艾滋病研究中使用的SPF恒河猴的病毒学和免疫学评价。 这些资源，再加上最近获得的SPF恒河猴群和熟练掌握最先进的遗传和人口管理的工作人员，使SWRPRC在满足艾滋病相关研究对SPF恒河猴的国家需求方面发挥了关键作用。 拟建项目将为SWRPRC提供必要的动物饲养设施，以充分发挥其潜力，满足国家研究需求。

DESCRIPTION (provided by applicant): The proposed construction will provide a complex of six buildings to be used for SPF Indian-origin rhesus monkeys and using them in AIDS-related research. The breeding facilities will consist of four buildings each with 14 indoor-outdoor cages. Total square footage of these buildings is 14,864. The breeding cages are separated into four buildings to reduce disease transmission. A climate-controlled building (544 sq. ft.) will be constructed in close association with the breeding cage buildings to be used for treating ill animals. It will have a treatment room, an isolation room and support rooms. The remaining building in the complex will be a personnel support facility. It will include two locker rooms, an office and a break room (624 sq. ft.). The SPF breeding colony to be housed in this complex is funded by a National Institutes of Health (NIH) Cooperative Agreement (U42-RR16024). Under this cooperative agreement, the SWRPRC will produce SPF rhesus monkeys for use primarily by NIH-grantees conducting AIDS-related research. The SWRPRC breeding colony, currently consisting of about 290 animals, is housed in a 40-year-old complex approximately 20 miles from the SWRPRC and on a military base that is scheduled to be turned over to the City of San Antonio in 2002. In addition to the operational difficulties of maintaining such a facility from a distance, the present facility can not accommodate the approximate doubling in colony size that is expected within the next four years. The SWRPRC combines experienced professional staff, proven methods, and excellent facilities for the virological and immunological evaluation of SPF rhesus macaques used in simian immunodeficiency virus (SIV)/AIDS research. These resources, combined with the recently acquired SPF rhesus colony and staff skilled in state-of-the-art genetic and demographic management, position the SWRPRC to play a pivotal role in meeting the national need for SPF rhesus in AIDS-related research. The proposed construction will provide the animal housing facilities necessary for the SWRPRC to fully realize its potential to meet this national research need.