INTRINSIC VISUAL CORTICAL NEURONS

描述：(改编自申请人的摘要) 一名调查员寻求五年的支持，以审查 大鼠视皮层的区域内反馈联系。四个目标是 建议。第一个目标是研究大脑中脑区的突触组织 前馈和反馈投射的抑制电路。这个 第二个目标将研究丘脑皮质通路的获得如何 可能会受到反馈预测的影响。第三个目标将检查 从解剖学上讲，前馈之间是否有直接联系 和反馈。最终目标将检查反馈是否 投射的有效性通过使用而改变，如果这种使用 依赖是通过NMDA机制运作的。

DESCRIPTION: (Adapted From The Applicant's Abstract) An investigator seeks support for five years to examine the role of intra-areal feedback connections in rat visual cortex. Four aims are proposed. The first aim will examine the synaptic organization of the inhibitory circuitry of the feedforward and feedback projections. The second aim will examine how the gain of the thalamocortical pathway might be regulated by feedback projections. The third aim will examine anatomically whether there are direct connections between feedforward and feedback. The final aim will examine whether the feedback projection's effectiveness is modified by use, and if this use dependence operates through an NMDA mechanism.