Molecular Genetics of Tumor Viruses and Cells

说明：(申请人提供)拟参加培训的目的 该计划是为高素质的男性和女性在 基础癌症研究。与过去一样，该计划的一个主要重点是 基本细胞过程的分子遗传学研究培训 与了解癌症的病因和最终发展有关 改进诊断和治疗方法。该项目的教职员工是 约翰斯大学分子生物学和遗传学系成员 霍普金斯大学医学院。所代表的研究兴趣 其中包括：肿瘤病毒基因组的复制 和细胞，生长因子和细胞增殖的调节 癌基因，哺乳动物细胞周期、结构和功能的控制 正常和肿瘤中基因表达的调控 生长，反转录转座子的分子遗传学，细胞的机制 信号转导与生长分化因子的作用 在发育和致癌方面。大学十四名教员中的五名 培训计划是NCI支持的计划项目赠款的成员，目前在 它的第二十五年，那是专注于基本的细胞机制， 控制细胞生长，维持基因组稳定。新增三名成员 得到美国癌症协会或其他私人癌症资助机构的直接支持 在过去的资助期内，虽然剩余的癌症相关工作 教师得到了其他机构(NIH和HHMI)的支持。 博士后(7名)和博士后(4名)受训人员都在此项下获得支持 培训补助金。博士前实习生必须有扎实的背景和 大学本科生在定量科学方面的成就，以及 最好有现代生物学的背景，包括遗传学。他们必须 第一次被跨部门生物化学研究生项目录取， 约翰霍普金斯大学细胞和分子生物学学院 并必须圆满地完成第一年的课程和实验室 那个节目的轮换。在第一年结束时，学生被挑选出来 进入肿瘤病毒分子遗传学和分子遗传学项目 平均每年约两个细胞，其稳定状态数量为 七。他们其余的培训包括实验室研究。 旨在鼓励创造力和自力更生，必修课程 与基础癌症研究相关的技术实践教学 现代分子遗传学，积极参与研究研讨会和 杂志俱乐部。 博士后实习生必须完成博士或 医学博士，必须有杰出的成就和创造的潜力 从事与癌症相关的基础或临床研究。他们花在 他们几乎所有的时间都是在 密切监督一名参与该项目的教职员工。他们也 积极参加研究研讨会和杂志俱乐部， 整个计划人员，并视情况参加与以下内容相关的正式课程 大学内开设癌症生物学课程。 该方案在招募和培训方面取得了长期的成功记录 杰出的基础调查人员。我们的大多数学生和 博士后实习生继续从事与癌症相关的基础研究 高质量的学术机构或制药/生物技术 组织。

DESCRIPTION: (provided by Applicant) The purpose of the proposed training program is to prepare highly qualified men and women for creative careers in basic cancer research. As in the past, a primary emphasis of the program is research training in the molecular genetics of fundamental cellular processes relevant to understanding the etiology of cancer and ultimately developing improved methods for diagnosis and treatment. The faculty of the Program are members of the Department of Molecular Biology and Genetics at the Johns Hopkins University School of Medicine. The research interests represented among the faculty include: the replication of the genomes of tumor viruses and cells, the regulation of cellular proliferation by growth factors and oncogenes, the control of the mammalian cell cycle, the structure and function of chromosomes, the regulation of gene expression in normal and neoplastic growth, the molecular genetics of retrotransposons, the mechanisms of cellular signal transduction, and the functions of growth and differentiation factors in development and carcinogenesis. Five of the fourteen faculty of the Training Program are members of an NCI-supported program project grant, now in its twenty-fifth year, that is focused on basic cellular mechanisms that control cell growth and maintain genomic stability. Three additional members received direct support from the ACS or other private cancer funding agencies during the past grant period, while the cancer-related work of the remaining faculty is supported by other agencies (NIH and HHMI). Both predoctoral (7) and postdoctoral (4) trainees are supported under this training grant. Predoctoral trainees must have a strong background and o u t standing undergraduate accomplishment in quantitative science, and preferably some background in modern biology including genetics. They must first be accepted into the interdepartmental Graduate Program in Biochemistry, Cellular and Molecular Biology at the Johns Hopkins University School of Medicine and must satisfactorily complete the first year course and laboratory rotations of that program. At the end of the first year students are selected for admission into the Program in Molecular Genetics of Tumor Viruses and Cells at an average rate of about two per year with a steady state number of seven. The remainder of their training consists of laboratory research designed to encourage creativity and self-reliance, required elective courses related to basic cancer research, practical instruction in the techniques of modern molecular genetics, and active participation in research seminars and journal clubs. Postdoctoral trainees must have completed the requirements for the Ph.D. or M.D. and must have outstanding accomplishment and potential for creative careers in cancer-related research at a basic or clinical level. They spend almost all of their time carrying out an individual research project under the close supervision of a faculty member participating in the program. They also participate actively in research seminars and journal clubs involving the entire program personnel and, as appropriate, take formal courses related to cancer biology offered within the University. The Program has a long record of success in recruiting and training outstanding basic investigators. The majority of our students and postdoctoral trainees go on to careers in basic research relevant to cancer at high quality academic institutions or pharmaceutical/biotechnology organizations.