CELLULAR AND MOLECULAR NEUROSCIENCE OF SURGERY SYSTEMS

描述（从申请人的摘要）：这个培训计划的目标是准备有前途的研究生和医学生，博士后和医疗住院研究员在感觉系统的细胞和分子神经科学的成功职业生涯。该计划源于在塑造我们所有感官功能的基本原则中进行综合训练的感知益处，并由以下概念框架指导：（I）人体的感觉系统是人类健康和福祉的基本贡献者，是疾病过程的关键基质。 (II)这些神经系统共享许多组织和功能的核心机制，这些机制在细胞、分子和遗传水平上尤其明显。(III)共同的机制也反映在感觉病理学中-特定的疾病过程通常影响多个感觉系统。 (IV)研究生和博士后研究培训将细胞，分子和遗传方面整合到一系列感觉系统中，将提高学员进行创新健康研究的能力。 核心机制跨越多个感觉系统，如疾病过程（例如Charcot-Marie-Tooth病、Norrie病、视网膜色素变性、Usher综合征、衰老和感觉衰老）。 因此，有必要进行研究培训，这种培训跨越了每个特殊感觉组织的传统界限。 拟议的培训学院由12名成员组成，他们具有听觉、化学感觉、机械感觉和视觉系统方面的专业知识。 教师的研究方法范围从诱变和分子遗传学，通过细胞和分子生物学，完整的动物生理学，行为分析和临床研究。机构资源，校外支持的水平和培训教师的培训历史产生一个极好的培训环境。

DESCRIPTION (from applicant's abstract): The goal of this training program is to prepare promising graduate and medical students, postdoctoral and medical resident fellows for successful careers in Cellular and Molecular Neuroscience of Sensory Systems. This program arises from the perceived benefits of integrated training in the fundamental principles which shape the function of all of our senses and is guided by the following conceptual framework: (I) The sensory systems of the human body are fundamental contributors to the health and well-being of people and are critical substrates for disease processes. (II) These neural systems share many core mechanisms of organization and function, which are especially apparent at the cellular, molecular and genetic levels. (III) Common mechanisms are also reflected in sensory pathologies- specific disease processes often impact multiple sensory systems. (IV) Graduate and postdoctoral research training which integrates cellular, molecular and genetic aspects over a range of sensory systems will enhance the ability of trainees to conduct innovative health-related research. Core mechanisms span multiple sensory systems as do disease processes (e.g. Charcot-Marie-Tooth disease, Norrie disease, Retinitis pigmentosa, Usher's syndrome, Aging and sensory senescence). Thus, there is a need for research training, which integrates across the traditional boundaries of each special-sense tissue. The proposed training faculty consists of 12 members with expertise in the auditory, chemosensory, mechanosensory and visual systems. Faculty research approaches range from mutagenesis and molecular genetics through cell and molecular biology, to intact animal physiology, behavioral analysis and clinical research. The institutional resources, level of extramural support and training histories of the training faculty engender a superb training environment.