A.S.P.E.N. RESEARCH WORKSHOP ON CLINICAL NUTRITION

讲习班已经并将继续与国家发展和发展研究所的工作人员密切协调组织。范哈伯德和迈克尔肯尼斯梅)。研讨会的形式是在每年的A.S.P.E.N.临床大会之前，将100名对临床营养的特定领域感兴趣和活跃的科学家聚集在一起，为期一天。研讨会由一名主席、联合主席和最多8名演讲者组成。主席和演讲者都是基础和临床研究领域的活跃科学家。通过演讲者和参与者之间的积极讨论，我们希望每年都能确定有希望的领域，以便在临床营养的选定主题上进行未来的研究和合作。讲习班的形式还将为青年科学家和研究员出席会议提供特别旅费，以鼓励他们积极参与。我们还建立了一个提交摘要奖励机制，专门针对每年来自年轻研究者的与研讨会主题相关的摘要。这些机制的设计是为了激发年轻科学家对研讨会的热情和积极参与，并将允许年轻研究者展示他们的工作，这些工作将被杰出的演讲者看到。去年（2001年）研讨会的主题是营养和炎症。本课题的背景是许多疾病（感染、自身免疫性疾病、炎症性肠病和癌症）的表现通常是由宿主内源性炎症介质（如前列腺素、细胞因子、一氧化氮、活性氧中间体和自由基）的释放产生的。在实验和临床研究中，特定营养素的施用可以调节介质释放的级联反应。药物营养素和饮食相关因素，如喂养方式和肥胖也会影响全身炎症反应。因此，实验证据表明，炎症反应可以通过控制营养物质的途径和组成而改变。这样的承诺已经推动了十多年的临床研究，但目前还没有一种特定的营养素可以说是任何特定疾病状态的标准治疗方法。2001年研讨会的目的是总结目前的知识状况，并确定是否可以提出关于临床使用这些药物的任何具体建议。

The workshop has and will continue to be organized in close coordination with NIDDK staff (Drs. Van Hubbard & Michael Kenneth May). The workshop format is to bring together for one day 100 scientists interested and active in specific areas of clinical nutrition each year prior to the annual A.S.P.E.N. Clinical Congress. The workshop is organized around a Chair, Co-Chair and up to 8 speakers. The Chairs and speakers are all active scientists in disciplines of both basic and clinical research. Through active discussion between and among speakers and participants, we hope to identify each year promising areas for future investigation and collaboration on the chosen topic in clinical nutrition. The format of the workshop will also solicit active participation of young scientists and fellows by providing special travel funds for their attendance at the meeting. We have also established a submitted abstract award mechanism targeted specifically for abstracts related to the workshop topic each year from younger investigators. These mechanisms are designed to foster excitement and active participation of younger scientists in the workshop and will allow junior investigators to present work that will be seen by the distinguished speakers. The topic for the proposed lst-year (2001) workshop is on nutrition and inflammation. The background for the topic is that manifestations of many diseases (infection, autoimmune disease, inflammatory bowel disease, and cancer) are often produced by the release of host endogenous inflammatory mediators (e.g. prostaglandins, cytokines, nitric oxide, reactive oxygen intermediates, and free radicals). In experimental and clinical studies, administration of specific nutrients can modulate the cascade of mediator release. Pharmaconutrients and dietary-related factors such as route of feeding and obesity can also influence systemic inflammatory response. Thus, experimental evidence would suggest that the inflammatory response may be altered by manipulation of route and composition of nutrients. Such promise has fueled over a decade of clinical investigation, yet no specific nutrient can be said yet to be standard therapy for any specific disease state. The purpose of the 2001 workshop is to summarize the current state of knowledge and to determine if any specific recommendation regarding use of these agents clinically can be advocated.