Attaching Graphene to Surfaces for Antimicrobial Applications

在过去的几年中，关于石墨烯(G)和氧化石墨烯（GO）与微生物相互作用的文献中有许多有趣的结果。然而，到目前为止看到的结果并不一致。文献报道了这两种材料不同程度的生物相容性和选择性，但人们普遍认为它们都具有杀菌作用。如此广泛的活性报道可能是由于石墨烯类材料可以作用于细胞的许多机制，包括：诱导氧化应激；由于边缘锋利而破坏膜；输送吸附的杂质；极大地改变了基材的刚度和粗糙度。在这个项目中，我们将使用表面接枝的聚合物刷链与吸附的石墨烯和氧化石墨烯制作新型纳米复合表面。我们将测试关于石墨烯和细胞相互作用的文献假设，目的是生产选择性抗菌涂层。

Over the past few years there have been many interesting results in the literature about the interaction of graphene (G) and graphene oxide (GO) with microorganisms. However, the results seen so far are inconsistent. The literature has reported varying degrees of biocompatibility and selectivity for the two materials but it is widely believed that they are both bactericidal. This wide range of reported activity is likely due there being a number of mechanisms by which graphene-type materials can act on cells including: inducing oxidative stress; disrupting membranes due to sharp edges; delivering adsorbed impurities; greatly changing substrate stiffness and roughness.In this project, we will make novel nanocomposite surfaces using surface-grafted polymer brush chains with adsorbed graphene and graphene oxide. We will test literature hypotheses regarding the interaction of graphene and cells, with the aim of producing selective antimicrobial coatings.