CENTRAL RHYTHMOGENESIS AND BEHAVIOR

描述(改编自摘要)：本项目的目的是 阐明健壮电节律性的作用和意义 下橄榄核神经元的分布及其与颞叶和额叶的关系 熟练运动的空间组织。在这个实验中， 首席调查员将使用多个微电极记录 大鼠熟练操作时体内浦肯野细胞复合体的棘波活动 用他们的口面部和四肢肌肉做动作。中央工作 该项目的假设是，所需的肌肉协同效应 多个肢体的协调运动取决于大脑的节律活动 从下脑到小脑的高度平行的投射。这 身体活动和有节奏的活动调节着运动系统。事实上，那就是 动物对人类下层的损害会永久性地破坏颞叶 熟练运动的空间结构牢固确立。vbl.使用 用老鼠进行高度控制的实验条件，调查者将 回答以下问题：橄榄小脑系统是否组织了 前爪-舌头运动的协同作用？如果是这样的话，是如何做到的呢？橄榄球的小脑 系统在时间上组织由双边产生空间引导的移动 肌肉学？如果是这样的话，是如何做到的呢？这两个主要传入神经之间是什么关系 小脑系统，爬行纤维和苔藓纤维，有 组织运动？不受控制的节律活动在 下橄榄驱动病理有节奏的运动，如所见 在肌阵挛发作期间？

DESCRIPTION (Adapted from the Abstract): The purpose of this project is to elucidate the function and significance of the robust electrical rhythmicity of the neurons in the inferior olive and their relation to the temporal and spatial organization of skilled movement. In this experiments, the Principal Investigator will employ multiple-microelectrode recordings of Purkinje cell complex spike activity in vivo while rats perform skilled movements with their oro-facial and limb muscles. The central working hypothesis of this project is that the muscle synergies required for coordinated movement of multiple limbs depend upon the rhythmic activity of the highly parallel projection from the inferior to the cerebellum. This activity physically and rhythmically modulates motor systems. Indeed, that damage to the inferior in humans animals permanently destroys the temporal and spatial structure of skilled movement is firmly established. Using highly controlled experimental conditions with rats, the Investigator will address the following questions: Does the olivocerebellar system organize a forepaw-tongue movement synergy? If so, how? Does the olivocerebellar system temporally organize a spatially-guided movement produced by bilateral musculature? If so, how? What relationship do the two major afferent systems of the cerebellum, the climbing and the mossy fibers, have in organizing movement? Does uncontrolled rhythmic activity within the inferior olive drive pathologically rhythmic movements, such as those seen during a myoclonic seizure?