SCIENTIFIC DEVELOPMENT OF A NEW EVOKED-RESPONSE METHOD

我们最近开发了一种用于诱发反应研究的新分析技术，该技术表明，被称为“听觉诱发40赫兹反应”的“稳态”反应实际上是由一系列重叠的瞬时诱发反应组成的，这是以前在人类或动物中没有记录到的。这些诱发的反应，我们称之为“G波”，具有潜在的意义，因为它们可能与皮层功能中的知觉“绑定”机制有关，也与知觉的某些方面有关。本申请描述了一个项目，研究揭示这些波的方法，以确保获得的波形有效。我们也会研究“白化”的降噪效果。这项基础研究与人类健康相关，因为它涉及一种监测大脑功能的新方法，这反过来可能有助于了解大脑功能障碍，特别是关于皮质生理学和感觉活动。记录技术使用非侵入性的头皮记录。这使得这些发现适用于心理生理学实验和临床测试。

We have recently developed a new analysis technique for evoked- response research that has shown that the "steady-state" response called the "auditory-evoked 40-Hz response" is actually made up of a series of overlapping transient evoked-responses, not previously recorded in humans or animals. These evoked responses, which we call "G-waves", have potential significance because of the possibility that they are related to mechanisms of perceptual "binding" in cortical function, as well as to some aspects of perception. This application describes a project to study the method that reveals these waves, so as to ensure that the obtained waveforms are valid. We will also study the effects of noise reduction using "whitening". This basic research has relevance to human health because it involves a new means to monitor the functioning of the brain, which in turn could help in understanding brain dysfunctions, especially as regards to cortical physiology and sensory activity. The recording techniques use non-invasive, scalp recordings. This makes the findings applicable to psychophysiological experiments, as well as to clinical tests.