SYMPOSIUM-AMERICAN CHEMICAL SOCIETY

描述(由申请人提供) 环境健康是公众和政府的优先事项。化学品 是我们享受的高生活水平的重要组成部分。这个 对环境健康科学家的挑战，包括毒物学家， 是为了确保我们不会危及我们的健康或环境 现代舒适生活的产物和副产品。在……里面 在这方面，分子毒理学已经变得越来越重要 学术、工业和监管领域的焦点。工具范围 从转基因技术到单细胞中的报告基因分析， 为研究化学品的影响提供了令人兴奋的机会 在他们的分子靶点，和/或理解调节和 这些相互作用的机制。此外，随着基因的出现， 芯片技术能够确定数以千计的响应 基因对化学诱导的压力现在不仅是可能的，而且 例行公事。此R13应用程序请求财务支持 研讨会，题为《基因表达的化学调控与压力》 答复“是在#司主持下编写的 化学毒理学，美国化学学会(ACS)的一个分会。 这次研讨会的目的不仅是评估最近在这方面的工作 研究领域，但也评估未来的方向在 细胞信号/基因表达中的化学和生物学交叉 研究。研讨会发言人的选择是由 让国际专家讨论不同的战略，但 化学诱导的应激反应的互补方面。因此， Orrenius教授的演讲将集中在线粒体及其关键部分 在化学诱导的细胞凋亡中的作用。史蒂文斯博士将讨论他最近的 关于内质网(ER)介导的性质的发现 对化学胁迫的反应。皮滕波尔博士凭借她的专业知识 在P53依赖的应激反应途径中，将讨论其性质 DNA损伤应激反应，从而完成了我们的旅途 参与蜂窝响应的选定区域设置 化学诱导的压力。最后，麦克劳德博士将提供更多 通过讨论细胞应激反应的变化来了解细胞应激反应的全球视角 全球基因表达对致癌物诱导的压力的响应。基金 请用于支付三个月的旅费和住宿费 特邀演讲者(Orrenius、Pietenpoll和Stevens)和四名毕业生 学生/博士后研究员。一位演讲者(麦克劳德)和 主席(僧侣)已经在其他地方得到了保障。

DESCRIPTION (provided by applicant) Environmental health is a public and governmental priority. Chemicals are an essential component of the high standard of living we enjoy. The challenge to environmental health scientists, including toxicologists, is to ensure that we are not endangering our health or the environment with the products and by-products of modem and comfortable living. In this respect, molecular toxicology has become an increasingly important focus of the academic, industrial and regulatory arena. Tools ranging from transgenic technologies to reporter gene assays in single cells are providing exciting opportunities for studying the effects of chemicals at their molecular targets, and/or understanding the regulation and mechanisms of these interactions. In addition, with the advent of gene chip technology the ability to determine the response of thousands of genes to a chemical-induced stress is now not only possible, but routine. This R13 application requests financial support for a symposium, titled "Chemical Modulation of Gene Expression and the Stress Response" that was prepared under the auspices of the Division of Chemical Toxicology, a section of the American Chemical Society (ACS). This symposium is designed not only to assess the recent work in this area of research, but also to assess future directions at the intersections of chemistry and biology in cell signaling/gene expression research. The selection of symposium speakers was dictated by the strategy of having international experts discuss differing, but complementary aspects of the chemical-induced stress response. Thus, Prof. Orrenius will focus his talk on the mitochondrion, and its pivotal role in chemical-induced apoptosis. Dr. Stevens will discuss his recent findings on the nature of the endoplasmic reticulum (ER) mediated response to chemical stress. Dr. Pietenpol, by virtue of her expertise in the p53-dependent stress response pathway, will discuss the nature of the DNA-damage stress response, thereby completing our sojourn through selected locales that participate in the cellular response to chemical-induced stress. Finally, Dr. MacCleod will provide a more global view of the cellular stress response by discussing changes in global gene expression in response to carcinogen-induced stress. Funds are requested to support the travel and accommodation expenses of three invited speakers (Orrenius, Pietenpol, and Stevens) and four graduate student/post-doctoral fellows. Funds for one speaker (MacLeod) and the Chair (Monks) have been secured elsewhere.