Human Disease and the Interplay Between Genes and the Environment

描述（由申请人提供） 美国亚利桑那大学（University of Arizona，U of A）提出建立人类基因与环境研究（Human Genes and the Environment Research，胡格）培训计划。胡格培训计划的发展受到几个重要现实的指导。与胡格TG最相关的是认识到，在未来几十年中，需要更精确地确定给定遗传背景下环境暴露对疾病过程的影响，以显着提高我们预测，检测，治疗和监测疾病进展和疾病反应的能力。此外，越来越清楚的是，表观遗传状态将成为一个受环境暴露调节的关键过程，导致该暴露的不利或有益表现。该胡格将建立在三个跨学科的前，和博士后培训计划不可或缺的创建一个成功的多学科培训计划，培训科学家在环境基因组学/遗传学。一个（i）NIEHS支持跨学科的毒理基因组学和毒理学培训计划，一个（ii）NSF跨学科研究生教育和研究培训（IGERT）计划在进化，功能和计算基因组学，和（iii）研究生跨学科计划（GIDP）在统计学提供了这个多学科倡议的演变的基础。胡格课程是专门为满足多学科培训计划的独特要求而创建的，其基石包括两门新课程，重新设计额外的课程，“工业”研究轮换，以及强调培养有能力和有效的沟通者。这对于需要跨学科有效沟通的新一代科学家尤为重要。A大学的培训环境还为学员提供了获得适当的当代计算和最先进技术的机会。培训计划学院由来自10个部门的17名科学家组成，在（i）环境和公共卫生科学与工程，（ii）人口和功能基因组学/遗传学，以及（iii）计算生物学和统计学/生物信息学领域积极开展研究计划。六个主要单位参加了胡格培训计划：[1]农业和生命科学学院; [2]工程学院; [3]医学院;[4]药学院; [5]公共卫生学院;[6]科学学院。其中五所学院参加了生物5研究所，该研究所汇集了来自不同学科的科学家，以解决复杂的生物学问题。胡格应用程序的副主任Vicki钱德勒博士是BIO 5的主任。为了确保该项目以其多学科重点而闻名，它将在行政上位于BIO 5内。

DESCRIPTION (provided by applicant) The University of Arizona (U of A) proposes to establishment of a Human Genes and the Environment Research (HuGER) Training Program. Development of the HuGER training program has been guided by several important realities. Most relevant to the HuGER TG is recognition of the fact that in the coming decades, a more precise determination of the influence of environmental exposures within a given genetic background on disease processes will be required to significantly improve our ability to predict, detect, treat and monitor disease progression and disease response. In addition it is increasingly clear that epigenetic status will emerge as a critical process that is modulated by environmental exposures, leading to the adverse or beneficial manifestation of that exposure. The HuGER will build upon three inter-disciplinary pre-, and post-doctoral training programs integral to the creation of a successful multi-disciplinary training program that trains scientists in environmental genomics/genetics. An (i) NIEHS supported inter-disciplinary training program in Toxicogenomics and Toxicology, an (ii) NSF Interdisciplinary Graduate Education and Research Training (IGERT) Program in Evolutionary, Functional, and Computational Genomics, and (iii) a Graduate Interdisciplinary Program (GIDP) in Statistics provide the foundation for the evolution of this multi-disciplinary initiative. The HuGER curriculum has been created specifically to address the unique requirements of a multi-disciplinary training program, the cornerstone of which includes two new courses, redesigning additional courses, "industrial" research rotations, and an emphasis on the development of competent and effective communicators. This is especially important for the new generation of scientists who will need to communicate effectively across multi-disciplinary boundaries. The training environment at the U of A also provides trainees with access to appropriate contemporary computing and state-of-the-art technologies. The Training Program Faculty consist of a core of 17 scientists, from 10 departments, with active research programs in the areas of (i) the environmental and public health sciences and engineering, (ii) population and functional genomics/genetics, and (iii) computational biology and statistics/bioinformatics. Six principal units are participating in the HuGER Training Program: [1] the College of Agriculture and Life Sciences; [2] the College of Engineering; [3] the College of Medicine [4] the College of Pharmacy; [5] the College of Public Health; and [6] the College of Sciences. Five of these Colleges participate in the BIO5 Institute which brings together scientists from disparate disciplines to solve complex biological problems. The Associate Director of this HuGER application, Dr. Vicki Chandler, is the Director of BIO5. To ensure the program is known for its multidisciplinary emphasis, it will be administratively housed within BIO5.