Human Disease and the Interplay Between Genes and the Environment

描述(由申请人提供) 亚利桑那大学提议建立一个人类基因和环境研究(HUGER)培训计划。豪格培训计划的发展是以几个重要的现实为指导的。与更大的TG最相关的是认识到这样一个事实，即在未来几十年，需要更准确地确定给定遗传背景内的环境暴露对疾病过程的影响，以显著提高我们预测、检测、治疗和监测疾病进展和疾病反应的能力。此外，越来越清楚的是，表观遗传状态将成为一个关键过程，受到环境暴露的调节，导致这种暴露的不利或有益表现。HIGER将建立在三个跨学科的博士后前和博士后培训计划的基础上，这三个计划是创建一个成功的多学科培训计划不可或缺的部分，该计划培训科学家环境基因组学/遗传学。(I)NIEHS支持的毒素基因组学和毒理学跨学科培训计划，(Ii)NSF进化、功能和计算基因组学跨学科研究生教育和研究培训(IGERT)计划，以及(Iii)统计学跨学科研究生计划(GIDP)，为这一多学科计划的发展奠定了基础。HIGER课程是专门为满足多学科培训计划的独特要求而创建的，该计划的基石包括两门新课程、重新设计附加课程、“工业”研究轮换，以及强调培养称职和有效的沟通者。这对于新一代科学家来说尤其重要，他们将需要跨越多学科的边界进行有效的沟通。阿肯色州大学的培训环境还为学员提供了接触适当的当代计算和最先进技术的机会。培训计划学院由来自10个系的17名科学家组成，他们在(I)环境和公共卫生科学和工程、(Ii)人口和功能基因组学/遗传学以及(Iii)计算生物学和统计学/生物信息学等领域开展积极的研究计划。参加大型培训方案的主要单位有六个：[1]农业和生命科学学院；[2]工程学院；[3]医学院[4]药学院；[5]公共卫生学院；[6]科学学院。这些学院中有五所参加了BIO5研究所，该研究所聚集了来自不同学科的科学家来解决复杂的生物学问题。这一大型应用程序的副主任Vicki Chandler博士是BIO5的主任。为了确保该项目以其多学科的重点而闻名，它将被行政地安置在BIO5内部。

DESCRIPTION (provided by applicant) The University of Arizona (U of A) proposes to establishment of a Human Genes and the Environment Research (HuGER) Training Program. Development of the HuGER training program has been guided by several important realities. Most relevant to the HuGER TG is recognition of the fact that in the coming decades, a more precise determination of the influence of environmental exposures within a given genetic background on disease processes will be required to significantly improve our ability to predict, detect, treat and monitor disease progression and disease response. In addition it is increasingly clear that epigenetic status will emerge as a critical process that is modulated by environmental exposures, leading to the adverse or beneficial manifestation of that exposure. The HuGER will build upon three inter-disciplinary pre-, and post-doctoral training programs integral to the creation of a successful multi-disciplinary training program that trains scientists in environmental genomics/genetics. An (i) NIEHS supported inter-disciplinary training program in Toxicogenomics and Toxicology, an (ii) NSF Interdisciplinary Graduate Education and Research Training (IGERT) Program in Evolutionary, Functional, and Computational Genomics, and (iii) a Graduate Interdisciplinary Program (GIDP) in Statistics provide the foundation for the evolution of this multi-disciplinary initiative. The HuGER curriculum has been created specifically to address the unique requirements of a multi-disciplinary training program, the cornerstone of which includes two new courses, redesigning additional courses, "industrial" research rotations, and an emphasis on the development of competent and effective communicators. This is especially important for the new generation of scientists who will need to communicate effectively across multi-disciplinary boundaries. The training environment at the U of A also provides trainees with access to appropriate contemporary computing and state-of-the-art technologies. The Training Program Faculty consist of a core of 17 scientists, from 10 departments, with active research programs in the areas of (i) the environmental and public health sciences and engineering, (ii) population and functional genomics/genetics, and (iii) computational biology and statistics/bioinformatics. Six principal units are participating in the HuGER Training Program: [1] the College of Agriculture and Life Sciences; [2] the College of Engineering; [3] the College of Medicine [4] the College of Pharmacy; [5] the College of Public Health; and [6] the College of Sciences. Five of these Colleges participate in the BIO5 Institute which brings together scientists from disparate disciplines to solve complex biological problems. The Associate Director of this HuGER application, Dr. Vicki Chandler, is the Director of BIO5. To ensure the program is known for its multidisciplinary emphasis, it will be administratively housed within BIO5.