Human Disease and the Interplay Between Genes and the Environment

人类疾病以及基因与环境之间的相互作用

• 批准号: 8307533
• 负责人: TERRENCE J. MONKS
• 金额: $ 17.8万
• 依托单位: UNIVERSITY OF ARIZONA
• 依托单位国家: 美国
• 财政年份: 2008
• 资助国家: 美国
• 起止时间: 2008-07-01 至 2014-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8307533
• 关键词: Environment; Genes; human disease

The University of Arizona (U of A) proposes the establishment of a Human Genes and the Environment Research (HuGER) Training Program. Development of the HuGER training program has been guided by several important realities. Most relevant to the HuGER TG is recognition of the fact that in the coming decades, a more precise determination of the influence of environmental exposures within a given genetic background on disease processes will be required to significantly improve pur ability to predict, detect, treat and monitor disease progression and disease response. In addition it is increasingly clear that epigenetic status will emerge as a critical process that is modulated by environmental exposures, leading to the adverse or beneficial manifestation of that exposure. The HuGER will build upon three inter-disciplinary pre-, and post-doctoral training programs integral to the creation of a successful multi-disciplinary training program that rains scientists in environmental genomics/genetics. An (i) NIEHS supported inter-disciplinary training Drogram in Toxicogenomics and Toxicology, an (ii) NSF Interdisciplinary Graduate Education and Research Training (IGERT) Program in Evolutionary, Functional, and Computational Genomics, and (iii) a Graduate nterdisciplinary Program (GIDP) in Statistics provide the foundation for the evolution of this multi-disciplinary nitiative. The HuGER curriculum has been created specifically to address the unique requirements of a multi-disciplinary training program, the cornerstone of which includes two new courses, redesigning additional courses, "industrial" research rotations, and an emphasis on the development of competent and effective communicators. This is especially important for the new generation of scientists who will need to communicate effectively across multi-disciplinary boundaries. The training environment at the U of A also Drovides trainees with access to appropriate contemporary computing and state-of-the-art technologies. The Training Program Faculty consist of a core of 17 scientists, from 10 departments, with active research programs in the areas of (i) the environmental and public health sciences and engineering, (ii) population and functional genomics/genetics, and (iii) computational biology and statistics/bioinformatics. Six principal units are participating in the HuGER Training Program: [1] the College of Agriculture and Life Sciences; [2 the College of Engineering; [3] the College of Medicine [4] the College of Pharmacy; [5] the College of Public Health; and [6] the College of Sciences. Five of these Colleges participate in the BIOS Institute which brings together scientists from disparate disciplines to solve complex biological problems. The Associate Director a this HuGER application, Dr. Vicki Chandler, is the Director of BIOS. To ensure the program is known for it multidisciplinary emphasis, it will be administratively housed within BIOS.

亚利桑那大学（U of A）提议建立人类基因与环境 研究（胡格）培训计划。胡格培训计划的制定一直受到以下指导： 几个重要的现实。与胡格TG最相关的是认识到， 几十年来，更精确地确定环境暴露对给定遗传物质的影响， 要显著提高疾病的预测、检测、治疗和预防能力， 并监测疾病进展和疾病反应。此外，越来越清楚的是，表观遗传 状态将成为一个关键过程，受到环境暴露的调节，导致不利的 或者是有益的表现该胡格将建立在三个跨学科的前， 博士后培训计划是创建一个成功的多学科培训计划的组成部分， 环境基因组学/遗传学方面的科学家。（一）国家环境卫生和健康战略支助的跨学科培训 毒理基因组学和毒理学中的Drogram，（ii）NSF跨学科研究生教育和研究 培训（IGERT）计划在进化，功能和计算基因组学，和（iii）研究生 统计学跨学科计划（GIDP）为这一多学科的发展奠定了基础 主动的胡格课程是专门为满足学生的独特要求而创建的。 多学科培训计划，其基石包括两个新的课程，重新设计 额外的课程，“工业”研究轮换，并强调发展能力和 有效的沟通者。这对新一代的科学家尤其重要，他们需要 跨学科的有效沟通。A大学的训练环境也 向受训人员提供适当的现代计算和最先进的技术。的 培训计划学院由来自10个部门的17名科学家组成，他们从事积极的研究 （一）环境和公共卫生科学与工程，（二）人口 和功能基因组学/遗传学，以及（iii）计算生物学和统计学/生物信息学。六个主要 参加胡格培训计划的单位：[1]农业和生命科学学院; [2] 工程学院; [3]医学院[4]药学院; [5]公共学院 [6]《大学生》（The College of Sciences）其中五所学院参加了BIOS研究所， 来自不同学科的科学家们聚集在一起，解决复杂的生物学问题。副主任a 这个胡格应用程序，Vicki钱德勒博士，是BIOS的主管。以确保该计划是众所周知的 该系统强调多学科，行政上将设在BIOS内。