NTX XIX 'PARKINSON'S DISEASE, ENVIRONMENT AND GENES'

描述（由申请人提供） 背景：在1999年11月的一次具有里程碑意义的会议上， 美国国立卫生研究院进行帕金森病（PD）研究的主要组成部分， 与患者倡导者合作，启动了一个规划过程， 确保有非凡的机会来治疗PD， 确保获得充分支持，并消除取得进展的重大障碍。 2000年1月4日至6日，一个包括校内、校外和工业界在内的研讨会， 科学家，来自几个帕金森病倡导组织的代表， 伦理学家讨论了PD研究的议程，并确定了需要重点关注的领域。 研究了 这些在NIH提交给国会的报告中进行了总结， 未来五年帕金森病重点研究议程 （第106-479号会议报告） 本次会议资助申请要求 来自主要NIH研究所的资金进行帕金森病（PD） 第19届国际神经毒理学会议（19 th International Neurotoxicology Conference） (NTX将于2001年8月25日至28日在科罗拉多州科罗拉多斯普林斯举行。 会议将围绕“帕金森病，环境和 基因. " 意义：“一种新的乐观主义认为帕金森病可以被击败， 激励研究社区和患者倡导者。 停止 PD的进展，恢复失去的功能，甚至预防疾病 都是现实的目标。 这一希望是由加速的步伐， 神经科学研究中的发现， 什么导致PD，以及广泛的新治疗方法，包括 干细胞移植，精密手术修复，慢性脑刺激， 和自然生长因子。 乐观情绪受到了 认识到我们还不能治愈任何主要的神经退行性疾病， 击败PD需要跨越医学的主要前沿”（NIH报告， Congress，2000）. 具体目标：最近有越来越多的证据表明， 环境暴露和遗传易感性在PD病因中的作用。 NTX XIX将解决NIH报告中确定的主要主题领域， 从跨学科的角度关注环境和基因的作用 视角，即，毒理学、流行病学、遗传学、暴露评估， 临床医学、药物开发和动物模型。 我们传统上 将遵循成功的会议形式;这包括： 演讲者，教程，以提供一个框架上建立，邀请 知名专家全体会议、非正式深入讨论小组、平台 从摘要中选出的最佳论文会议，海报会议， 博士后和研究生最佳演讲奖，以鼓励 该领域的年轻研究人员这些主题的世界级专家一直在 确定、邀请和大多数已经同意参加。 来自学术界，工业界，政府，特殊利益集团， 包括基金会和病人倡导者。 新的和国家的科学 研究将被提出和讨论，研究建议将被 为每个主题分类。 正如前18次会议所做的那样， NTX XIX的论文将经过同行评审并迅速发表。

DESCRIPTION (provided by applicant) Background: At a landmark meeting in November 1999, the directors and staff of the major components of NIH conducting Parkinson's disease (PD) research, working together with patient advocates, initiated a planning process to ensure that extraordinary opportunities to move toward a cure for PD are adequately supported and that critical obstacles to progress are addressed. On January 4-6, 2000, a Workshop including intramural, extramural and industry scientists, representatives from several Parkinson's advocacy groups, and ethicists discussed an agenda for PD research and identified major areas to be investigated. These were summarized in an NIH Report to Congress outlining a research agenda for Parkinson's focused research for the next five years (Conference Report No. 106-479). This conference grant application requests funds from the major NIH Institutes conducting Parkinson's disease (PD) research to help support the 19th International Neurotoxicology Conference (NTX XIX) to be held August 25-28, 2001 in Colorado Springs, CO. The NTX XIX Conference will focus on the theme of "Parkinson's Disease, Environment and Genes." Significance: "A new optimism that Parkinson's disease can be defeated is energizing the research community and patient advocates. Halting the progression of PD, restoring lost function, and even preventing the disease are all realistic goals. This hope is fueled by the accelerating pace of discovery in neuroscience research generally, by advances in understanding what causes PD, and by a wide range of new treatments on the horizon including stem cell transplants, precision surgical repair, chronic brain stimulation, and natural growth factors to name a few. Optimism is tempered by the recognition that we cannot yet cure any major neurodegenerative disorder, and defeating PD requires crossing a major frontier of medicine" (NIH Report to Congress, 2000). Specific Aims: There is recent and increasing evidence of interaction between environmental exposures and genetic susceptibility in the etiology of PD. NTX XIX will address the major topic areas identified in the NIH Report while focusing on the role of environment and genes from an interdisciplinary perspective, i.e., toxicology, epidemiology, genetics, exposure assessment, clinical medicine, drug development and animal models. Our traditionally successful conference format will be followed; this includes: keynote speakers, tutorials to provide a framework on which to build, invited plenaries by recognized experts, informal in-depth discussion groups, platform sessions for the best papers selected from abstracts, poster session, post-doctoral and graduate student awards for best presentations to encourage young researchers in the field World class experts on these topics have been identified, invited and the most already have agreed to participate. Representatives from academia, industry, government, special interest groups, foundations and patient advocates are included. New and state-of-the-science research will be presented and discussed and research recommendations will be itemized for each topic. As has been done for the 18 previous conferences, papers from NTX XIX will be peer-reviewed and rapidly published.