BIOCHEMISTRY AND IMMUNOLOGY OF ALCOHOLIC LIVER DISEASE

说明： 酒精性肝病是一个严重的世界性问题。虽然一个很大的 已经进行了大量的研究，以确定 与酗酒有关的肝脏损害的责任仍然不是 明确导致肝细胞损伤的机制。有一个 需要训练有素的基础科学家来研究细胞和 酒精性肝病的分子生物学方面。这是一个非常新的 发现酗酒与更严重的肝炎有关 丙型肝炎病毒，这进一步支持了这样一种说法 免疫反应的抑制和增加之间的联系 对肝炎病毒等传染病的易感性。很少 关于导致更严重的 感染了这些病毒，显然需要个人 在酒精影响的这一方面接受过训练。 需要经过临床培训的研究人员，了解 研究。许多医学博士项目的创建已经被提议用来填补 需要经过研究训练的临床医生。这是拟议的 培训助学金，用于培训医学博士研究生从事临床工作 可以对酒精性肝病的发病机制进行研究。 建议将培训学院设在奥马哈退伍军人管理局 奥马哈大学研究人员与奥马哈大学研究人员合作 内布拉斯加州医学中心和克雷顿大学，培养博士前 (包括医学博士/博士研究生)和博士后 酒精中毒的基本发病机制。我的培训教职员工已经 内布拉斯加州大学医学中心的学术任命和 积极资助研究，并在培训前具有丰富的经验 以及博士后。 鉴于培训人员的专业知识，可用的广泛资源 对受训者和多学科方法的酒精中毒研究 奥马哈退伍军人管理局研究单位的肝脏疾病很可能每个受训人员 将完全有资格继续酒精研究的研究生涯。这个 该培训计划的最终目标是为基础科学家和 经过临床培训的科学家，为积极和富有成效的研究生涯 酒精对肝脏的影响。

DESCRIPTION: Alcoholic liver disease is a serious world-wide problem. Although a large amount of research has been done to determine the mechanisms that are responsible for liver damage associated with alcohol abuse it is still not clear what the mechanisms are that result in hepatocyte damage. There is a need for well-trained basic scientists to do research on the cellular and molecular biological aspects of alcoholic liver disease. It is a very recent finding that alcohol abuse is associated with a more severe hepatitis caused by hepatitis C virus, which has further supported the suggestion that there is an association between the suppression of immune responses and an increased susceptibility to infectious agents such as the hepatitis viruses. Very little information is available regarding the mechanisms that lead to more severe infections with these viruses and there is a clear need for individuals trained in this aspect of alcohol's effects. There is a need for clinically trained researchers with an understanding of research. The creation of numerous MD/PhD programs has been proposed to fill the need for research-trained clinicians. It is one aspect of the proposed training grant to train MD/PhD students to assume positions where clinical research on the mechanisms of alcoholic liver disease can be performed. It is proposed that the training faculty located at the Omaha VA Medical Center in Omaha, in collaboration with investigators at the University of Nebraska Medical Center and Creighton University, train pre-doctoral (including MD/PhD students) and post-doctoral students in research in the fundamental mechanisms of alcoholic Ever disease. 'Me training faculty have academic appointments at the University of Nebraska Medical Center and are actively funded to do research and have extensive experience in training pre- and post-doctoral students. Given the expertise of the training faculty, the extensive resources available to the trainees and the multidisciplinary approach to research on alcoholic liver disease at the Omaha VA research unit it is likely that each trainee will be well qualified to continue a research career in alcohol research. The ultimate goal of this training program is to prepare both basic scientists and clinically trained scientists for an active and productive research career on the effects of alcohol on the liver.