DRUG EXCRETION IN TRANSPLANT PATIENTS

本研究的目的是评估肾移植患者的肾功能。 在这里，通过给肾移植患者施用肾标记物-PAH、碘酞酸盐和头孢氨苄来确定肾功能，以研究活性肾小管阴离子分泌、过滤和活性肾小管分泌。 12名肾移植患者将被分为两组，6名将在3小时内接受碘酞酸盐（IOH）和PAH，另外6名将接受头孢氨苄推注，并在8小时内进行研究。 将在收集的血浆和尿液中测定药物，并将结果与接受Ioth/PAH的6名正常人进行比较。

The objective of this study is to access renal function in renal transplant patients. Here kidney function is determined by administering renal markers--PAH, Iothalamate and Cephalexin to renal transplant patients to study active tubular anionic secretion, filtration, and active tubular secretion. Twelve kidney transplant patients will be divided into two groups, six will receive Iothalamate (IOH) and PAH over a three hour period, the other six will receive Cephalexin as a bolus and studied over eight hours. Drugs will be assayed in plasma and urine collected, and results compared with six normals receiving Ioth/PAH.