Study of Salvage Regimens for Patients with HIV Infection Demonstrating Virologi

高活性抗逆转录病毒疗法已经彻底改变了HIV疾病的治疗，但相当一部分患者在治疗的前3年内要么从未应答，要么失去病毒学控制。在这项研究中，HAART失败的患者接受了三种药物治疗。该研究有两个主要目标：（1）确定对这些药物的反应率，（2）确定哪些临床和实验室参数，特别是基因型和表型分析，可用于预测反应。已完成98例患者的累积;所有患者均已达到48周随访。结果表明，表型检测可用于预测对挽救治疗方案的反应，并且毒性是常见的，特别是对于高病毒载量的患者。基因型测定也可用于预测反应，但其解释比表型测定复杂得多。目前正在编写最后手稿。

Highly active antiretroviral therapy has revolutionized the therapy of HIV disease, yet a substantial fraction of patients either never respond, or lose virologic control during the first 3 years of therapy. In this study, patients who have failed HAART were treated with three agents. The study had two major goals: (1) to determine the response rate to these agents, and (2) to determine what clinical and laboratory parameters, especially genotypic and phenotypic analysis, are useful for predicting response. Accrual of 98 patients has been completed; all have reached 48 weeks of followup. Results show that phenotypic assays are useful for predicting response to salvage regimens, and that toxicity is common, especially for patients with high viral loads. Genotypic assays were also useful for predicting response, but their interpretation is much more complex than for phenotypic assays. A final manuscript is being prepared.