INHALATION TOXICITY OF VOLATILE ORGANIC CHEMICALS--CARBON DISULFIDE

工作总结：在过去十年中，公众和科学界对慢性神经退行性疾病的认识急剧上升，最近，随着知名人士披露其神经系统疾病及其与环境化学品的潜在关联，慢性神经退行性疾病的认识达到了历史最高水平。 公众担心二硫化碳的潜在神经毒性。 目的是提供更好的关于二硫化碳（CS2）如何影响人类健康的机制数据。 另一个目标是在神经毒性研究期间提供神经系统完整性的详细描述。神经毒性准则的一个共同主题是，应综合所有现有数据，对任何可能的神经毒性危害提供连贯的描述。 负责评估和管理与复杂神经系统有关的风险的监管机构高度重视这一综合情况。 该评估需要整合来自神经学、行为学、电生理学和病理学终点的数据。 研究是通过内部吸入动物研究完成的，目前正在与当地大学的科学家和环境保护局的科学家合作继续进行。正在评估大鼠和小鼠之间的比较中枢神经系统研究。

Summary of Work: Public and scientific awareness of chronic neurodegenerative disease has risen dramatically during the last decade and recently reached an all time high with the disclosure by well-known individuals of their nervous system maladies and the potential association with environmental chemicals. The public is concerned about the potential neurotoxicity of carbon disulfide. The goal is to provide better mechanistic data on how carbon disulfide (CS2) can affect human health. Another goal is to provide detailed descriptions of the nervous system integrity during neurotoxicity studies. A common theme among neurotoxicity guidelines is that all available data should be integrated to provide a coherent description of any possible neurotoxic hazards. This integrated picture is valued highly by regulators who have the responsibility for assessing and managing risk connected with the complex nervous system. The assessment requires integration of data from neurological, behavioral, electrophysiological and pathological endpoints. Research was accomplished through in-house inhalation animal studies and is being continued through collaborative efforts with scientists at local universities and with EPA scientists. Comparative central nervous system studies between the rat and mouse are being evaluated.