3Dimensional Reactions: A new Approach to Chemical Catalysis using 3D Printed Devices

生产活性药物成分（api）的化学反应的规模从药物发现实验室的毫克量到过程实验室的大型千吨反应器不等。在这两种情况下，反应是通过内部磁性跟随器或更大的外部控制的反应器桨混合的。在一种新的方法中，希尔顿集团开发了新颖的专利3D打印设备，可用于有效混合反应，其中含有浸渍催化剂，可以同时混合和催化化学反应，使整个过程更容易进行。该设备是在希尔顿实验室使用3D打印生产的，在打印时将催化剂浸渍在设备中。这些设备用于加速药物发现过程，指导从发现到过程实验室的合成。这个令人兴奋的新项目将涉及探索这些设备的范围，以催化一系列反应，并开发新的设备和应用。该项目将探索可纳入催化剂的范围及其催化一系列化学反应的潜力。采用的主要方法和技术：该项目专注于与3D打印相结合的合成化学，这是一个新兴且快速发展的领域。该项目将涉及化学合成以及新型3D打印设备的设计和开发。使用的技术将包括化学合成、催化、3D设计、3D打印和自动净化。我们也鼓励参与这个项目的学生在这个新颖的领域发表尽可能广泛的文章。

Chemical reactions to produce active pharmaceutical ingredients (APIs) are carried out on scales ranging from milligram amounts in drug discovery laboratories through to large kiloton reactors in process laboratories. In both cases, reactions are mixed via internal magnetic follower or via larger externally controlled reactor paddles. In a new approach, the Hilton group has developed novel patented 3D Printed devices that can be used to efficiently mix reactions and which contain impregnated catalysts to both mix and catalyse chemical reactions at the same time, making the entire process simpler to carry out. The devices are produced using 3D printing in the Hilton laboratory and the catalyst is impregnated in the device at the point of printing.These devices are used to speed up the drug discovery process, guiding synthesis from discovery through to process laboratories. This new and exciting project will involve exploring the scope of these devices to catalyse a range of reactions andthe development of new devices and applications. The project will explore the scope of catalysts that can be incorporated and their potential to catalyse a range of chemical reactions.Main Methods and Techniques to be employed:The project focuses on synthetic chemistry alligned with 3D printing in a novel and fast growing area. The project will involve chemical synthesis and the design and development of novel 3D printed devices. Techniques used will include chemical synthesis, catalysis, 3D Design, 3D printing and automatic purification. The student employed in the project will also be encouraged to publish as widely as possible in this novel area.