4.7T Magnetic Resonance Console

描述(由申请人提供)：申请资金购买新的电子产品 控制台和磁场梯度/垫片线圈系统以取代现有的 4.7特斯拉33厘米内径水平磁共振成像(MRI)设备 磁铁。通过这种最先进的技术来支持和大大增强的项目 高性能仪器属于神经科学(功能)领域 脑成像应用和开发，脑药理学，癌症， 神经血管病理学、神经退行性变)、生物矿化(发育 骨生物学，骨矿和基质组成及晶体结构， 骨的非侵入性成像/无损评估和工程化 生物材料)和血管生物学(多模式/多光谱成像 动脉壁和动脉粥样硬化斑块)。 现有的控制台和梯度系统已不能满足需要 支持的项目，并且不再受制造商支持。这个 升级后的仪器性能显著增强，将显著 提高在这些研究中获得的磁共振数据的质量。最重要的是，新的 这些项目的实验机会将成为可能，但不可能 仅与现有仪器一起考虑。 这一新仪器将支持的研究项目包括 多学科，横跨多个部门和机构， 包括几家医院和大学。这些项目涉及基本的 科学和公共卫生问题。

DESCRIPTION (provided by applicant): Funding is requested for a new electronics console and magnetic field gradient/shim coil system to replace existing equipment on a 4.7 Tesla 33 cm bore horizontal magnetic resonance imaging (MRI) magnet. Projects to be supported and vastly enhanced with this state of the art high performance instrumentation fall in the areas of neuroscience (functional brain imaging applications and development, brain pharmacology, cancer, neurovascular pathology, neurodegeneration), biomineralization (developmental biology of bone, bone mineral and matrix composition and crystal structure, noninvasive imaging/nondestructive evaluation of bone and engineered biomaterials), and vascular biology (multimodality/multispectral imaging of arterial walls and atherosclerotic plaque). The existing console and gradient system are no longer adequate for the needs of the supported projects, and are no longer supported by the manufacturer. The strikingly enhanced performance of the upgraded instrument will dramatically improve the quality of MR data obtained in these studies. Most importantly, new experimental opportunities for these projects will become possible that cannot be considered with only the existing instrumentation. The research projects to be supported by this new instrumentation are multidisciplinary, cutting across several departments and institutions, which include several hospitals and universities. The projects address a mix of basic scientific and public health issues.