Kansas Mental Retardation Research Center

要求为堪萨斯大学精神发育迟滞和发育障碍研究中心（MRDDRC）的竞争性更新提供五年的核心支持。堪萨斯州的MRDDRC，现在在其第34个年头，发挥了重要作用，在产生有效的干预措施，目的是在原因，预防和治疗精神发育迟滞，并在划定的基本知识的基础生物学的典型和非典型的发展。基于这一丰富的历史，该中心在未来的一个独特的贡献将是生物信息的行为和药理学干预和治疗方法的发展。在这一生物行为方向的背景下，堪萨斯MRDDRC的使命是支持高质量的基础和应用研究有关的原因和预防精神发育迟滞和预防和补救与精神发育迟滞和相关的发展障碍的继发性疾病。为了实现这一使命，堪萨斯MRDDRC旨在实现三个目标。首先，提供具有成本效益的、最先进的核心服务、资源和设施，直接提高与中心相关的项目产生的科学质量。第二，为规划、发展、管理、协调和传播与中心有关的研究活动提供有效的、具有成本效益的系统。第三，在中心研究人员之间，以及在中心研究人员与美国和世界各地其他研究中心的研究人员之间，发展和支持与中心使命直接相关的新的跨学科基础和应用研究倡议。堪萨斯MRDDRC的研究计划围绕四个主题领域组织，反映了我们当前工作的科学方向和优势。这些主题是：1）语言、交流障碍和智力低下的认知; 2）智力低下的风险、预防和干预; 3）智力低下的神经生物学; 4）早期发育的细胞和分子生物学。为了协调和支持66名研究人员的研究活动和与这些主题相关的72个研究项目，提出了五个核心单位：a）行政服务和通信; B）生物行为测量; c）研究设计和分析; d）生物行为成像和图形; c）组织培养和单克隆抗体。

Core support for five years is requested for the competitive renewal of the Kansas University Mental Retardation and Developmental Disabilities Research Center (MRDDRC). The Kansas MRDDRC, now in its 34th year, has played a major role in generating effective interventions aimed at the causes, prevention, and treatment of mental retardation, and in delineating basic knowledge of the underlying biology of typical and atypical development. Building on this rich history, a unique contribution of the Center in the future will be the development of biologically informed behavioral and pharmacological intervention and treatment approaches. Within the context of this biobehavioral direction, the mission of the Kansas MRDDRC is to support high quality basic and applied research relevant to the causes and prevention of mental retardation and the prevention and remediation of secondary conditions associated with mental retardation and related developmental disabilities. To achieve this mission, the Kansas MRDDRC is designed to accomplish three objectives. First, to provide cost effective, state of the art core services, resources, and facilities that directly enhance the quality of science produced by projects associated with the Center. Second, to provide efficient, cost-effective systems for planning, developing, managing, coordinating, and disseminating research activities associated with the center. Third, to develop and support new interdisciplinary basic and applied research initiatives directly relevant to the center's mission among center investigators, and between center investigators and investigators at other research centers throughout the United States and the World. The Kansas MRDDRC's research program is organized around four thematic areas that reflect the scientific directions and strengths of our current efforts. These themes are: 1) language, communication disorders, and cognition of mental retardation; 2) risk, prevention, and intervention in mental retardation; 3) neurobiology of mental retardation; 4) cellular and molecular biology of early development. To coordinate and support the research activities of the 66 investigators and 72 research projects associated with these themes, five core units are proposed: a) Administrative Services and Communication; b) Biobehavioral Measurement; c) Research Design and Analysis; d) Biobehavioral Imaging and Graphics; c) Tissue Culture and Monoclonal Antibodies.