REPBASE UPDATE- A DATABASE OF REPETITIVE SEQUENCES

Repbase更新(http://www.girinst.org)，是一个全面的DNA序列集合，目前代表来自所有真核物种的1200多个重复元件家族和亚家族。每个家庭都可以通过一个唯一的名字来识别，参考已出版的文献，并经常在简短的评论中描述。在过去的两年里，Repbase更新中增加了数百个重复的家庭，这些家庭要么在其他地方没有报道，要么在他们的共识序列和生物学分类方面得到了彻底的修改。我们的方法是基于对公开可用的DNA序列数据的计算机辅助探索和分析。Repbase更新经常被世界各地的公共机构和私人公司用于常规的基因发现、序列组装和探针设计。此外，Repbase更新成为具有生物和医学重要性的单个研究项目的独特资源。鉴于预计将有大量新的序列数据，我们建议继续开发、维护和以电子方式传播这一资源。特别是，我们希望发现并描述数百个新的重复家族，这些家族将继续以电子方式发表在Repbase更新上。此外，我们将继续汇编和组织所有真核物种的已报道的重复序列家族。最后，我们将维护用于自动注释人类和啮齿动物重复序列的公共服务器，并生成哺乳动物基因组DNA中存在的重复元件的最新注释。具体来说，我们建议：1.继续开发、维护和电子分发来自所有已测序的真核生物物种的重复元件的参考集合。2.生成存在于可用哺乳动物基因组DNA序列中的重复元件的公共区域图。

Repbase Update (http://www.girinst.org), is a comprehensive collection of DNA sequences, currently representing over 1200 families and subfamilies of repetitive elements from all eukaryotic species. Each family is identifiable by a unique name, referenced to published literature and often characterized in brief commentaries. Several hundreds of repetitive families added to Repbase Update during the last two years are either unreported anywhere else, or have been thoroughly revised in terms of their consensus sequences and biological classification. Our approach is based on computer-assisted exploration and analysis of publicly available DNA sequence data. Repbase Update has been routinely used by public institutions and private companies throughout the world in routine gene discovery, sequence assembly and probe design. In addition, Repbase Update became a unique resource for individual research projects of biological and medical importance. In light of the anticipated flood of new sequence data, we propose continuation of development, maintenance and electronic dissemination of this resource. In particular, we expect to discover and characterize hundreds of new repetitive families which will continue to be published electronically in Repbase Update. Furthermore, we will continue to compile and organize reported families of repeats from all eukaryotic species. Finally, we will maintain the public server for automatic annotation of human and rodent repeats and generate up-to-date annotation of repetitive elements present in genomic DNA of mammals. In particular we propose to: 1. Continue development, maintenance and electronic distribution of reference collections of repetitive elements from all sequenced eukaryotic species. 2. Generate public domain maps of repetitive elements present in available mammalian genomic DNA sequences.