Pre-doctoral Training in Integrative Vascular Biology

描述（由申请人提供）： 心血管疾病的发病机制复杂。 然而， 受过处理整个机体疾病训练的调查人员正在减少。 因此，我们建议培养能够实施综合管理的科学家。 结合“细胞”、“整个动物”和“人类”系统的方法。 这是 只有通过多学科合作才有可能开始 在博士前培训期间。 因此，我们开发了一种跨学科的 在综合血管生物学（IVB）博士前培训计划，在 北卡罗来纳州大学，其既定目标是激励学生 合作 为了鼓励这种多学科方法，我们需要 学生有两个互补的顾问。 每年将有四名学员 从已经参加部门课程的研究生中挑选， 课程设置 增加学生选择导师的自由， 为了将他们团结成一个IVB团体，我们将支持他们长达三年。 IVB计划由校园范围内的分子计划管理 生物学和生物技术。 Nobuyo Maeda博士，病理学教授， 医学实验室主任 论文指导老师是教师 (from北卡罗来纳大学三所学校和一所学院的12个系），拥有强大的 致力于通过血管生物学相关研究进行博士前培训 在分子、细胞和整个生物体水平上， 给人类患者的模型。 补充培训教师包括 临床教师和个人在剑桥和附近的机构， 研究三角区，主要维持活跃的实验室， 博士后研究生。 我们的教师之间的广泛合作已经 多学科博士前综合培养的存在与机制 血管生物学已经就位并发挥作用。 所需资金将 使我们能够正式化和扩大我们的IVB计划，并实施 小组指导，确保学员在一个以上的机构开展研究 实验室 凭借其在血管生物学研究方面的杰出历史， 强大的研究团队，以及其在动物模型研究方面的优势， IVB计划为多学科培训提供了出色的环境 博士前学生。

DESCRIPTION (provided by applicant): The pathogenesis of cardiovascular diseases is complex. Yet the number of investigators trained to deal with whole organism diseases is decreasing. Accordingly, we propose to train scientists capable of implementing integrated approaches combining "cellular", "whole animal" and "human" systems. This is only possible through multidisciplinary collaborations that should begin during predoctoral training. We have therefore developed an interdisciplinary program for predoctoral training in Integrative Vascular Biology (IVB) at the University of North Carolina with the stated goal of stimulating students to collaborate. To encourage this multi-disciplinary approach, we require students to have two complementing advisors. Four trainees a year will be selected from graduate students already enrolled in departmental programs and curricula at UNC. To increase the students' freedom in choosing advisors, and to unite them as an IVB group, we will support them for up to three years. The IVB Program is administered by the campus-wide Program for Molecular Biology and Biotechnology. Dr. Nobuyo Maeda, Professor of Pathology and Laboratory Medicine, is Director. The thesis advisors are faculty members (from 12 Departments in three Schools and one College at UNC), with a strong commitment to predoctoral training through vascular biology related research at the molecular, cellular, and whole organism levels ranging from animal models to human patients. The complementing training faculty includes clinical faculty and individuals at UNC and nearby Institutions in the Research Triangle area who maintain active laboratories mainly with postdoctoral students. Extensive collaborations among our faculty already exist and the mechanism of multidisciplinary pre-doctoral training in integrated vascular biology is already in place and functional. The requested funding will allow us to formalize and expand our IVB Program and implement the concept of group-mentoring by ensuring that trainees carry out their research in more than one laboratory. With its outstanding history in vascular biology research, its strong group of investigators, and its strength in animal model studies, the IVB Program offers an outstanding environment for multidisciplinary training of predoctoral students.