Basic Science Cardiovascular Training Progam

(申请人摘要) 这一基础科学心血管训练计划，目前正处于第24期 年，为计划全日制学术研究的个人提供博士后培训 在高血压研究领域从事心血管科学的职业， 动脉粥样硬化，以及缺血性心脏病和心力衰竭。基础训练 在分子生物学、遗传学、基因组学、生物化学、 药理学、生理学、心肌和血管细胞生物学，以及在 将这些学科应用于研究领域。培训现场 是惠特克心血管研究所的基础科学实验室 和波士顿大学医学院的埃文斯生物医学研究中心 中心。这项研究得到了SCOR两项拨款、三项计划项目的支持 助学金以及众多个人助学金。该计划是 多学科，包括各系的教职员工参与 医学、生物化学、生物物理学、生理学和药理学。最多的 该计划的重要方面，也是实习生的主要活动，是 受训人员在直接监督下进行的研究 作为教导员的实验室主任。正规课程和研讨会 补充研究经验。该计划旨在提供内部- 深度培训和产生有资格独立执行任务的调查人员， 在指定领域进行高质量、原创性的研究。候选人持有 招聘适当领域的医学博士和/或博士学位。每个人 申请者由资深人士组成的委员会评估并接受或拒绝 科学家。医生实习生被要求完成他们的第一次 临床培训。要求为12名博士后实习生提供支持 这代表着继续保持目前的支助水平。每个人 学员将在培训计划中停留2-3年。所有的 教官的实验室至少有一笔大的资助；他们很好 配备了最先进的动物外科、心脏和 血管生理学，分子生物学，转基因动物的发展， 扫描和透射电子显微镜、X射线衍射、气体和高 加压液相色谱、质谱学、分析 超速离心、荧光激活细胞分选、共聚焦显微镜、 组织培养、器官培养、氨基酸分析仪、蛋白质测序仪和 核磁共振和电子顺磁共振波谱。

(Applicant's Abstract) This Basic Science Cardiovascular Training Program, currently in its 24th year, offers postdoctoral training to individuals planning full-time academic careers in cardiovascular science in research areas of hypertension, atherosclerosis, and ischemic heart disease and heart failure. Basic training is offered in molecular biology, genetics, genomics, biochemistry, pharmacology, physiology, myocardial and vascular cell biology, and in the application of these disciplines to the research areas. The training sites are the basic science laboratories of the Whitaker Cardiovascular Institute and the Evans Biomedical Research Center of the Boston University Medical Center. The research is supported by two SCOR grants, three program project grants as well as numerous individuals grants. The program is multidisciplinary and includes faculty participation from the Departments of Medicine, Biochemistry, Biophysics, Physiology, and Pharmacology. The most important aspect of the program, and the major activity of the trainee, is the research performed by the trainee under the direct supervision of the laboratory director who serves as preceptor. Formal courses and seminars supplement the research experience. The program is designed to provide in- depth training and produce investigators qualified to perform independent, high-quality, original research in the designated areas. Candidates holding the M.D. and/or Ph.D. degrees in appropriate fields are recruited. Each applicant is assessed and accepted or rejected by a committee of senior scientists. Physician trainees are required to have completed their initial clinical training. Support is requested for 12 post-doctoral trainees per year; this represents continuation of the current level of support. Each trainee will remain in the training program for 2-3 years. All of the preceptors' labs are funded by at least one major grant; they are well equipped with state-of-the-art facilities for animal surgery, cardiac and vascular physiology, molecular biology, development of transgenic animals, scanning and transmission electron microscopy, X-ray diffraction, gas and high pressure liquid chromatography, mass spectroscopy, analytic ultracentrifugation, fluorescent activated cell sorting, confocal microscopy, tissue culture, organ culture, amino acid analyzers, protein sequencers and NMR and EPR spectroscopy.