Training Program in Basic and Translational Cardiovascular Science

摘要 这是一个培训计划的更新申请，该计划在其第9年寻求资助，以支持博士前和 心血管和血管疾病多学科研究项目的博士后研究生 从分子和细胞研究、成像、生物医学工程到转化科学。期间 在上一个资金周期，我们已经非常成功地扩大了我们的培训计划，从31个教师五 40年前，在这场竞争激烈的更新中，我们培训计划的教师来自五个不同的 学校/学院。事实上，培训计划对我们的机构产生了高度的协同影响;我们 通过机构资助，成功建立了新的心血管研究中心（CVRC） 来自加州大学戴维斯分校的五所不同的学校和学院，将于2017年秋季推出。课程和 在培训方案内开展的活动已被用作其他培训赠款的模式， 在校园里进行翻译研究，因此，在加州大学戴维斯分校为更广泛的学员群体服务。 该计划在内科学系和研究生院的主持下运作， 分子，细胞和综合生理学（MCIP），药理学和毒理学（PTX），生物化学， 分子，细胞和发育生物学（BMCDB），生物物理学（BPH）和生物医学工程 (BME)这是一个真正的多学科计划。培训计划的目标是生产一种新的混合物， 科学家们随时准备交流思想，专业知识和技术，从而直接有效地交流 将基础科学发现转化为临床试验和应用，并产生 可以在基本细胞水平上进行测试的机制假设，直接来自临床研究。 这样一个综合方案的优势是巨大和深远的。通过将临床导师合并在一起 我们的目标是培养新的博士生， 博士后研究人员不仅能够建立独立的研究，而且还善于 识别并整合相关的基础科学问题，使其成为临床上相关的答案和解决方案。

ABSTRACT This is a renewal application of a training program in its 9th year that seeks funding to support predoctoral and postdoctoral research trainees in a multidisciplinary research program in cardiovascular and vascular diseases spanning from molecular and cellular studies, imaging, biomedical engineering, to translational science. During the last funding cycle, we have been highly successful in expanding our training program from 31 faculty five years ago to 40 faculty in this competing renewal. The faculty in our Training Program are from five different schools/Colleges. Indeed, the training program has had a highly synergistic impact on our institution; we have been successful in establishing a new Cardiovascular Research Center (CVRC) through institutional funding from five different schools and colleges at UC Davis which will be launched in Fall 2017. The curriculum and activities developed within the training program have been used as models for other training grants in translational research on campus and hence, serve a wider group of trainees at UC Davis. The Program operates under the auspices of the Department of Internal Medicine and the Graduate Studies in Molecular, Cellular and Integrative Physiology (MCIP), Pharmacology and Toxicology (PTX), Biochemistry, Molecular, Cellular and Developmental Biology (BMCDB), Biophysics (BPH) and Biomedical Engineering (BME), a truly multidisciplinary program. The goal of the Training Program is to produce a new blend of scientists who are poised to exchange ideas, expertise, and techniques leading to the direct and effective flow and translation of basic science discoveries into clinical testing and applications, as well as generate mechanistic hypotheses that can be tested at the basic cellular level, directly derived from clinical research. The advantages of such an integrated program are vast and far reaching. By merging clinical mentors together with pre-doctoral and post-doctoral trainees in basic science, our objectives are to foster new Ph.D.s and postdoctoral researchers who are not only capable of establishing independent research, but are also adept to recognizing and integrating relevant basic science questions into clinically germane answers and solutions.