Training Program In Basic & Translational Cardiovascular Science

描述(由申请人提供)：这是一个培训项目的首次竞争性续签申请，该项目寻求资金支持一个多学科研究项目的博士后、博士后和临床学员，该项目涵盖从分子和细胞研究、成像、生物医学工程到特别强调心血管和血管疾病的翻译科学。在上一个资助周期中，我们非常成功地将我们的培训计划从四年前的25名教职员工扩大到这次竞争性续签的31名教职员工。我们培训计划中的教师来自五所不同的学校/学院。通过培训计划，我们已经成功地在加州大学戴维斯分校建立了医生科学家轨道(2 2)计划，以获得心脏病学奖学金。两名博士后实习生已经毕业，目前正在继续他们的博士后研究人员培训。一名博士后实习生已被提升为初级教职员工。在培训计划内开发的课程和活动已被用作校园翻译研究的其他培训补助金的范本，因此，服务于加州大学戴维斯分校更广泛的受训者群体。培训计划的目标是培养新的科学家和临床科学家，他们准备交流想法、专业知识和技术，从而直接和有效地将基础科学发现转化为临床测试和应用，并产生可以在基础细胞水平上进行测试的机械假说，这些假说直接来自临床研究。通过将临床科学家实习生与基础科学博士后和博士后实习生合并在一起，我们的目标是培养新的博士和博士后/临床医生科学家，他们不仅能够建立独立的研究，而且善于识别和整合相关的基础科学问题和与临床相关的答案和解决方案。该计划由内科和分子、细胞和综合生理学(MCIP)、药理学和毒理学(PTX)、生物化学、分子、细胞和发育生物学(BMCDB)和生物医学工程(BME)研究生课程主持，是一个真正的多学科课程。培训计划包括必修的核心课程、暑期学校、期刊俱乐部和心血管科学热点、负责任的研究行为课程、心血管研讨会、基础和翻译学习小组、生物统计学和流行病学课程、拨款撰写和生存技能课程。这样一个综合计划的优势是巨大和深远的。基础和临床实习生可以开始交流想法、专业知识和技术，从而直接和有效地将基础科学发现转化为临床测试和应用，并产生可以在直接来自临床研究的基础水平上进行测试的机械假说。(摘要结束)

DESCRIPTION (provided by applicant): This is a resubmission application of the first competing renewal application of a training program that seeks funding to support predoctoral, postdoctoral, as well as clinical trainees in a multidisciplinary research program spanning from molecular and cellular studies, imaging, biomedical engineering, to translational science with special emphasis in cardiovascular and vascular diseases. During the last funding cycle, we have been highly successful in expanding our training program from 25 faculty four years ago to 31 faculty in this competing renewal. The faculty in our Training Program are from five different schools/Colleges. Through the training program, we have been successful in establishing the Physician Scientist track (2+2) program for cardiology fellowship at UC Davis. Two predoctoral trainees have graduated and are now continuing their training as postdoctoral researchers. One postdoctoral trainee has been promoted to a junior faculty position. The curriculum and activities developed within the training program have been used as models for other training grants in translational research on campus and hence, serve a wider group of trainees at UC Davis. The goal of the Training Program is to produce a new blend of scientists and clinician scientists who are poised to exchange ideas, expertise, and techniques leading to the direct and effective flow and translation of basic science discoveries into clinical testing and applications, as well as generate mechanistic hypotheses that can be tested at the basic cellular level, directly derived from clinical research. By merging clinician scientist trainees together with pre-doctoral and post-doctoral trainees in basic science, our objectives are to produce new Ph.D.s and postdoctoral/clinician scientists who are not only capable of establishing independent research, but are also adept to recognizing and integrating relevant basic science questions/problems into clinically germane answers and solutions. The Program operates under the auspices of the Department of Internal Medicine and the Graduate Studies in Molecular, Cellular and Integrative Physiology (MCIP), Pharmacology and Toxicology (PTX), Biochemistry, Molecular, Cellular and Developmental Biology (BMCDB) and Biomedical Engineering (BME), a truly multidisciplinary program. The training program includes required core courses, Summer School, Journal Clubs and Hot Topics in Translational Cardiovascular Sciences, courses in Responsible Conduct of Research, Cardiovascular Symposium, Basic and Translational Learning Groups, courses in biostatistics and epidemiology, grant writing, and survival skills. The advantages of such an integrated program are vast and far reaching. Basic and clinical trainees can begin to exchange ideas, expertise, and techniques leading to the direct and effective flow and translation of basic science discoveries into clinical testing and applications as well as the generation of mechanistic hypotheses which can be tested at the fundamental level directly derived from clinical research. (End of Abstract)