Training Program In Basic & Translational Cardiovascular Science

描述（由申请人提供）：这是一个培训计划的第一个竞争性更新申请的重新提交申请，该培训计划寻求资金，以支持多学科研究计划中的博士前，博士后以及临床学员，该研究计划涵盖分子和细胞研究，成像，生物医学工程，转化科学，特别强调心血管和血管疾病。在上一个资金周期，我们已经非常成功地扩大我们的培训计划，从25名教师四年前到31名教师在这个竞争性的更新。我们培训计划的教师来自五所不同的学校/学院。通过培训计划，我们已经成功地建立了加州大学戴维斯分校心脏病学奖学金的医生科学家轨道（2+2）计划。两名博士前学员已经毕业，目前正在继续接受博士后研究人员培训。一名博士后实习生已晋升为初级教员。在培训计划中开发的课程和活动已被用作校园翻译研究的其他培训赠款的模型，因此，为加州大学戴维斯分校更广泛的学员群体服务。 该培训计划的目标是产生一个新的科学家和临床科学家谁是准备好交换思想，专业知识和技术，导致直接和有效的流动和基础科学发现转化为临床测试和应用，以及生成机制假设，可以在基本细胞水平进行测试，直接从临床研究中得出。通过将临床科学家学员与基础科学的博士前和博士后学员合并在一起，我们的目标是培养新的博士和博士后/临床科学家，他们不仅能够建立独立的研究，而且还善于识别和整合相关的基础科学问题/问题到临床密切相关的答案和解决方案。 该计划在内科和分子，细胞和综合生理学（MCIP），药理学和毒理学（PTX），生物化学，分子，细胞和发育生物学（BMCDB）和生物医学工程（BME），一个真正的多学科计划的研究生课程的主持下运作。培训计划包括必需的核心课程，暑期学校，期刊俱乐部和转化心血管科学的热门话题，负责任的研究行为课程，心血管研讨会，基础和转化学习小组，生物统计学和流行病学课程，赠款写作和生存技能。这样一个综合方案的优势是巨大和深远的。基础和临床学员可以开始交流思想，专业知识和技术，从而直接有效地将基础科学发现转化为临床测试和应用，以及生成可以在基础水平上直接从临床研究中进行测试的机制假设。(End摘要）

DESCRIPTION (provided by applicant): This is a resubmission application of the first competing renewal application of a training program that seeks funding to support predoctoral, postdoctoral, as well as clinical trainees in a multidisciplinary research program spanning from molecular and cellular studies, imaging, biomedical engineering, to translational science with special emphasis in cardiovascular and vascular diseases. During the last funding cycle, we have been highly successful in expanding our training program from 25 faculty four years ago to 31 faculty in this competing renewal. The faculty in our Training Program are from five different schools/Colleges. Through the training program, we have been successful in establishing the Physician Scientist track (2+2) program for cardiology fellowship at UC Davis. Two predoctoral trainees have graduated and are now continuing their training as postdoctoral researchers. One postdoctoral trainee has been promoted to a junior faculty position. The curriculum and activities developed within the training program have been used as models for other training grants in translational research on campus and hence, serve a wider group of trainees at UC Davis. The goal of the Training Program is to produce a new blend of scientists and clinician scientists who are poised to exchange ideas, expertise, and techniques leading to the direct and effective flow and translation of basic science discoveries into clinical testing and applications, as well as generate mechanistic hypotheses that can be tested at the basic cellular level, directly derived from clinical research. By merging clinician scientist trainees together with pre-doctoral and post-doctoral trainees in basic science, our objectives are to produce new Ph.D.s and postdoctoral/clinician scientists who are not only capable of establishing independent research, but are also adept to recognizing and integrating relevant basic science questions/problems into clinically germane answers and solutions. The Program operates under the auspices of the Department of Internal Medicine and the Graduate Studies in Molecular, Cellular and Integrative Physiology (MCIP), Pharmacology and Toxicology (PTX), Biochemistry, Molecular, Cellular and Developmental Biology (BMCDB) and Biomedical Engineering (BME), a truly multidisciplinary program. The training program includes required core courses, Summer School, Journal Clubs and Hot Topics in Translational Cardiovascular Sciences, courses in Responsible Conduct of Research, Cardiovascular Symposium, Basic and Translational Learning Groups, courses in biostatistics and epidemiology, grant writing, and survival skills. The advantages of such an integrated program are vast and far reaching. Basic and clinical trainees can begin to exchange ideas, expertise, and techniques leading to the direct and effective flow and translation of basic science discoveries into clinical testing and applications as well as the generation of mechanistic hypotheses which can be tested at the fundamental level directly derived from clinical research. (End of Abstract)