Training Program In Basic & Translational Cardiovascular Science

描述（由申请人提供）：这是一个培训项目的第一个竞争性更新申请的重新提交申请，该项目寻求资助，以支持从分子和细胞研究、成像、生物医学工程到特别强调心血管和血管疾病的转化科学的多学科研究项目的博士前、博士后和临床实习生。在上一个资助周期中，我们非常成功地将我们的培训项目从四年前的25名教员扩大到这次竞争性更新中的31名教员。我们培训项目的教师来自五个不同的学校/学院。通过培训计划，我们已经成功地建立了加州大学戴维斯分校心脏病学奖学金的医师科学家轨道（2+2）计划。两名博士预科生已经毕业，正在继续接受博士后培训。一名博士后实习生被提升为初级教员。在培训项目中开发的课程和活动已被用作校园翻译研究的其他培训资助的模型，因此，为加州大学戴维斯分校更广泛的学员群体提供服务。培训计划的目标是培养一种新的科学家和临床科学家的混合，他们准备好交流思想，专业知识和技术，从而直接有效地将基础科学发现转化为临床试验和应用，并产生可以在基本细胞水平上测试的机制假设，直接从临床研究中获得。通过将临床科学家学员与基础科学的博士预科和博士后学员合并，我们的目标是培养新的博士和博士后/临床科学家，他们不仅能够建立独立的研究，而且善于识别相关的基础科学问题/问题并将其融入临床相关的答案和解决方案。该计划在内科和分子，细胞和综合生理学（MCIP），药理学和毒理学（PTX），生物化学，分子，细胞和发育生物学（BMCDB）以及生物医学工程（BME）的研究生课程的主持下运作，这是一个真正的多学科计划。培训计划包括必修的核心课程、暑期学校、期刊俱乐部和转化心血管科学的热门话题、负责任的研究行为课程、心血管研讨会、基础和转化学习小组、生物统计学和流行病学课程、拨款写作和生存技能。这样一个综合方案的优势是巨大而深远的。基础和临床培训生可以开始交流思想、专业知识和技术，从而直接有效地将基础科学发现转化为临床试验和应用，并产生可以直接从临床研究中得到的在基础水平上进行测试的机制假设。（摘要结束）

DESCRIPTION (provided by applicant): This is a resubmission application of the first competing renewal application of a training program that seeks funding to support predoctoral, postdoctoral, as well as clinical trainees in a multidisciplinary research program spanning from molecular and cellular studies, imaging, biomedical engineering, to translational science with special emphasis in cardiovascular and vascular diseases. During the last funding cycle, we have been highly successful in expanding our training program from 25 faculty four years ago to 31 faculty in this competing renewal. The faculty in our Training Program are from five different schools/Colleges. Through the training program, we have been successful in establishing the Physician Scientist track (2+2) program for cardiology fellowship at UC Davis. Two predoctoral trainees have graduated and are now continuing their training as postdoctoral researchers. One postdoctoral trainee has been promoted to a junior faculty position. The curriculum and activities developed within the training program have been used as models for other training grants in translational research on campus and hence, serve a wider group of trainees at UC Davis. The goal of the Training Program is to produce a new blend of scientists and clinician scientists who are poised to exchange ideas, expertise, and techniques leading to the direct and effective flow and translation of basic science discoveries into clinical testing and applications, as well as generate mechanistic hypotheses that can be tested at the basic cellular level, directly derived from clinical research. By merging clinician scientist trainees together with pre-doctoral and post-doctoral trainees in basic science, our objectives are to produce new Ph.D.s and postdoctoral/clinician scientists who are not only capable of establishing independent research, but are also adept to recognizing and integrating relevant basic science questions/problems into clinically germane answers and solutions. The Program operates under the auspices of the Department of Internal Medicine and the Graduate Studies in Molecular, Cellular and Integrative Physiology (MCIP), Pharmacology and Toxicology (PTX), Biochemistry, Molecular, Cellular and Developmental Biology (BMCDB) and Biomedical Engineering (BME), a truly multidisciplinary program. The training program includes required core courses, Summer School, Journal Clubs and Hot Topics in Translational Cardiovascular Sciences, courses in Responsible Conduct of Research, Cardiovascular Symposium, Basic and Translational Learning Groups, courses in biostatistics and epidemiology, grant writing, and survival skills. The advantages of such an integrated program are vast and far reaching. Basic and clinical trainees can begin to exchange ideas, expertise, and techniques leading to the direct and effective flow and translation of basic science discoveries into clinical testing and applications as well as the generation of mechanistic hypotheses which can be tested at the fundamental level directly derived from clinical research. (End of Abstract)