Training Program in Basic and Translational Cardiovascular Science

描述（申请人提供）： 这是一个项目的申请，该项目旨在寻求资金支持多学科研究项目的博士前，博士后以及临床实习生，该项目涵盖分子和细胞研究，成像到转化科学，特别强调与心血管疾病相关的膜相关蛋白。该培训计划的目标是培养一批新的科学家和临床科学家，他们随时准备交流思想，专业知识和技术，从而将基础科学发现直接有效地转化为临床测试和应用，并产生可以在基本细胞水平上进行测试的机制假设，直接来自临床研究。通过将临床科学家学员与基础科学的博士前和博士后学员合并在一起，我们的目标是培养新的博士和博士后/临床科学家，他们不仅能够建立独立的研究，而且善于识别和整合相关的基础科学问题/问题到临床密切相关的答案和解决方案。 该计划将在内科学系和分子，细胞和综合生理学，药理学和毒理学，细胞和发育生物学以及生物医学工程研究生课程的主持下运作，这是一个真正的多学科计划，由来自四所不同学校/学院的教师组成，包括医学院，兽医学院，加州大学戴维斯分校工程学院和农业与环境科学学院。培训师将包括21名教员培训师和4名副教员培训师，研究项目包括细胞/分子生物学、生物化学、生理学、生物医学工程和转化研究。研究培训计划将通过所需的核心课程，暑期学校，期刊俱乐部和转化心血管科学的热门话题，年度务虚会，基础和转化学习小组以及生物统计学和流行病学，生物伦理学，赠款写作和生存技能以及职业相关问题的正式课程进行增强。这样一个综合方案的优势是巨大和深远的。基础和临床学员可以开始交流思想，专业知识和技术，从而直接有效地将基础科学发现转化为临床测试和应用，以及生成可以在基础水平上直接从临床研究中进行测试的机制假设。

Description (provided by applicant): This is an application for a program that seeks funding to support pre-doctoral, post-doctoral as well as clinical trainees in multidisciplinary research program spanning from molecular and cellular studies, imaging to translational science with special emphasis in membrane-associated proteins related to cardiovascular disorders. The goal of this Training Program is to produce a new blend of scientists and clinician scientists who are poised to exchange ideas, expertise, and techniques leading to the direct and effective flow and translation of basic science discoveries into clinical testing and applications, as well as generate mechanistic hypotheses that can be tested at the basic cellular level, directly derived from clinical research. By merging clinician scientist trainees together with pre-doctoral and post- doctoral trainees in basic science, our objectives are to produce new Ph.D.s and postdoctoral/clinician scientists who are not only capable of establishing independent research, but are also adept to recognizing and integrating relevant basic science questions/problems into clinically germane answers and solutions. The Program will operate under the auspices of the Department of Internal Medicine and the Graduate Studies in Molecular, Cellular and Integrative Physiology, Pharmacology and Toxicology, Cellular and Developmental Biology and Biomedical Engineering, a truly multidisciplinary program that consists of faculty from four different schools/Colleges including School of Medicine, School of Veterinary Medicine, School of Engineering and College of Agricultural and Environmental Sciences at University of California, Davis. The Trainers will include 21 Faculty Trainers and 4 Associate Faculty Trainers with research programs ranging from cellular/molecular biology, biochemistry, physiology, biomedical engineering and translational research. The research training program will be enhanced with required core courses, Summer School, Journal Clubs and Hot Topics in Translational Cardiovascular Sciences, Annual Retreats, Basic and Translational Learning Groups as well as formal courses in biostatistics and epidemiology, bioethics, grant writing and survival skills and career-related issues. The advantages of such an integrated program are vast and far reaching. Basic and clinical trainees can begin to exchange ideas, expertise, and techniques leading to the direct and effective flow and translation of basic science discoveries into clinical testing and applications as well as the generation of mechanistic hypotheses which can be tested at the fundamental level directly derived from clinical research.