ROLE FOR MATERNAL HOMOCYST(E)INE IN FETAL METABOLISM?

关于胎儿血液中同型胞浆(E)含量的数据没有 可用。我们检验了同型胞体(E)因穿过 母体/胎盘/胎儿间期，并被胎儿隔离。 在分娩时测定同型半胱氨酸的浓度。 35例未分娩健康孕妇外周静脉血的检测 和脐动、静脉血浆。 结果显示血浆浓度梯度呈下降趋势 同型囊(E)从母体静脉到脐静脉和到脐带 各间期的降幅约为1umol/L。 新生儿体重和胎龄与母亲体重呈负相关。 同型胞液(E)浓度。脐静脉到脐动脉 同型半胱氨酸减少表明发生了对同型半胱氨酸的摄取 在胎儿中。同型胞苷(E)可能被掺入 胎儿代谢周期可能与母体同型包囊(E) 对胎儿有潜在的营养作用。进一步的研究是 需要解释同型半胱氨酸在胎儿新陈代谢中的作用 发展。资助GCRC RR080出版物Malinow先生，Rajkovic A， DUELL PB，Hess DL，Upson BS。母体与母体的关系 新生儿脐带血浆同型胞浆(E)提示潜在的 母体同型囊(E)碱在胎儿代谢中的作用。Am J Obstet 妇科杂志178：228-233,1998。

Data on fetal blood homocyst(e)ine concentrations are not available. We tested the hypothesis that homocyst(e)ine crosses the maternal/placental/fetal interphases and is sequestered by the fetus. The concentration of homocyst(e)ine was determined at parturition in peripheral venous plasma from 35 nulliparous healthy pregnant women and umbilical arterial and venous plasma from their conceptus. Findings demonstrated a descending concentration gradient of plasma homocyst(e)ine from maternal vein to umbilical vein and to umbilical artery; the decrease at each interphase approximated 1 umol/L. The neonate weight and gestational age were inversely related to maternal homocyst(e)ine concentrations. The umbilical vein to umbilical artery homocyst(e)ine decrement suggests that uptake of homocyst(e)ine occurs in the fetus. The likely incorporation of homocyst(e)ine into the fetal metabolic cycle may implicate maternal homocyst(e)ine as having a potential nutritional role in the fetus. Further studies are required to explain the role of homocyst(e)ine in fetal metabolism and development. FUNDING GCRC RR080 PUBLICATIONS Malinow MR, Rajkovic A, Duell PB, Hess DL, Upson BS. The relationship between maternal and neonatal umbilical cord plasma homocyst(e)ine suggests a potential role for maternal homocyst(e)ine in fetal metabolism. Am J Obstet Gynecol 178:228-233, 1998.