Dense Array EEG for Neonatal Sleep Monitoring

描述(申请人提供)：脑电图仪是一种安全的， 无创监测新生儿脑功能的技术。急性和 婴幼儿脑电长期监测对评估患儿预后有临床应用价值 缺氧缺血对癫痫患者的影响及癫痫患者的检测 活动。新生儿脑电中可获得的信息可以通过以下方式大大增强 使用足够数量的电极来准确地标绘空间 无空间混叠的脑电分布。测地线新生儿脑电 大脑监测器将从实验研究和理论上设计 婴幼儿头皮电位所需采样密度的模拟 头。将开发密集阵列EEG方法，将独特的 婴幼儿颅骨解剖学特征评价婴幼儿脑内发育潜能 婴儿。测地线新生儿脑电监测系统将适用于 各种临床用途，最初侧重于监测大脑功能 睡在新生儿重症监护病房(NICU)。这项监测将检查 新生儿的正常和病理睡眠状态，提供信息 早产儿和足月儿唤醒控制成熟度的研究 对了解婴儿猝死综合征有重要意义。 建议的商业应用： 行为结果研究表明，新生儿的大脑功能经常处于危险之中。 重症监护室。一种廉价、高分辨率的新生儿大脑状态监测器可以 指导医疗管理以支持大脑健康，从而改善神经学 以及许多婴儿的心理结果。

DESCRIPTION (provided by applicant): Electroencephalography is a safe, noninvasive technique for monitoring neonatal brain function. Acute and long-term EEG monitoring of infants has clinical utility for evaluating the effects of hypoxic ischemic insults and detecting the presence of epileptic activity. The information available in neonatal EEG can be greatly enhanced by using an adequate number of electrodes to accurately map the spatial distribution of the EEG without spatial aliasing. The Geodesic Neonatal EEG Brain Monitor will be designed from experimental studies and theoretical simulations of the required sampling density for scalp potentials on the infant head. Dense Array EEG methods will be developed that incorporate the unique features of infant skull anatomy to estimate the potentials in the brain of the infant. The Geodesic Neonatal EEG Brain Monitor system will be adapted for a variety of clinical uses, initially focusing on monitoring brain function in sleep in the Neonatal Intensive Care Unit (NICU). This monitoring will examine both normal and pathological sleep states of the neonate, providing information on the maturation of arousal control in preterm and full term infants that may be important in understanding sudden infant death syndrome. PROPOSED COMMERCIAL APPLICATION: Behavioral outcome studies indicate that brain function is often at risk in the neonatal intensive care unit. An inexpensive, high-resolution neonatal brain state monitor could guide medical management to support brain health and therefore improve neurological and psychological outcome in many infants.